2013 Fiscal Year Final Research Report
Probucol attenuates gentamicin-induced cochlear hair cell loss by inhibition of apoptosis.
| Project/Area Number |
23592474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKIGI Akinobu 東京大学, 医学部附属病院耳鼻咽喉科, 講師 (60243820)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 内耳有毛細胞 / 抗脂血症薬 / アポトーシス |
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| Research Abstract |
Probucol is one of the representative lipid-lowering agent with anti-inflammatory and antioxidant properties that has a long history of clinical application for the treatment and prevention of cardiovascular diseases. Recently, several studies have revealed its neuroprotective property. However, to date, protective effect of probucol for cochlear hair cell remains to be elucidated. In the present using cochlear explant culture for 24 h, probucol attenuated hair cell loss and apoptosis induced by 0.3 micro M of gentamicin. Moreover, 100 micro M of probucol was most effective, suggesting that there is an optimal concentration for protective effect. These results revealed the neuroprotective effect of probucol in cochlear hair cells.
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