2013 Fiscal Year Final Research Report
Mechanism of cell death and development of a new therapy against noise-induced hearing loss
Project/Area Number |
23592482
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANZAKI Sho 慶応義塾大学, 医学部付属病院, 講師 (50286556)
FUJITA Takeshi 神戸大学, 医学部付属病院, 特定助教 (90533711)
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Project Period (FY) |
2011 – 2013
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Keywords | 内耳 / 再生 / アポトーシス |
Research Abstract |
We first manufactured the animal models that became hearing loss induced by intense noise. In the hearing loss animal model, we elucidated the mechanism which led to the cell death (apoptosis) of inner hair cells. Finally, based on these results, we examined the method that hearing loss was treated by various kinds of approaches, and the results that might cure hearing loss in the both sides where were in hearing function / inner ear morphology were obtained.
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[Journal Article] Serum and tissue metabolomics of head and neck cancer2013
Author(s)
Yonezawa K, Nishiumi S, Kitamoto-Matsuda J, Fujita T, Morimoto K, Yamashita D, Saito M, Otsuki N, Irino Y, Shinohara M, Yoshida M, Nimu KI
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Journal Title
Cancer Genomics & Proteomics
Volume: 10(5)
Pages: 233-238
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