Elucidation and innovative drug development development of the cytokine network in the condition of a patient formation of acidophile-related sinusitis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592511
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Okayama University
• Principal Investigator: OKANO Mitsuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (60304359)
• Co-Investigator(Kenkyū-buntansha): KARIYA Shin 岡山大学, 岡山大学病院, 助教 (10274226)
• Project Period (FY): 2011 – 2013
• Keywords: サイトカイン / 副鼻腔炎 / 好酸球 / 黄色ﾌﾞﾄﾞｳ球菌 / 真菌 / プロテアーゼ / プロスタグラシン / 衛生仮説

Research Abstract

We sought to determine the extrinsic and intrinsic factors involving the pathogenesis of eosinophilic rhinosinusitis. We found that microbial components including exotoxins in Staphylococcus aureus, fungal antigens, TLR agonists and proteases regulates cytokine networks including IL-5, IL-13, IFN-gamma, IL-17A, IL-18, IL-33, IL-22 and IL-10, and involved in the pathogenesis of eosinophilic rhinosinusitis including nasal polyp formation, eosinophil infiltration into nasal polyps, radiological severity of rhinosinusitis, and lower airway obstruction.

Research Products

• [Journal Article] Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps (2014)
  • Author(s): Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Matsushita O, Noda Y, Makihara S, Kanai K, Noyama Y, Taniguchi M, Nishizaki K
  • Journal Title: Allergology International Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis (2014)
  • Author(s): Kariya S, Okano M, Oto T, Higaki T, Makihara S, Haruna T, Nishizaki K
  • Journal Title: Journal of Laryngology and Otology Volume: 128 Pages: 255-262
  • DOI: 10.1017/S0022215114000450.
  • Peer Reviewed
• [Journal Article] Cystatin SN upregulation in patients with seasonal allergic rhinitis (2013)
  • Author(s): Imoto Y, Tokunaga T, Matsumoto Y, Hamada Y, Ono M, Yamada T, Ito Y, Arinami T, Okano M, Noguchi E, Fujieda S
  • Journal Title: PLoS One Volume: 8 Pages: e67057
  • DOI: 10.1371/journal.pone.0067057
  • Peer Reviewed
• [Journal Article] Determining minimal clinically important differences in Japanese cedar/cypress pollinosis (2013)
  • Author(s): Higaki T, Okano M, Kariya S, Fujiwara T, Haruna T, Hirai H, Murai A, Gotoh M, Okubo K, Yonekura S, Okamoto Y, Nishizaki K
  • Journal Title: Allergolgy International Volume: 162 Pages: 487-493
  • DOI: 10.2332/allergolint.13-OA-0570.
  • Peer Reviewed
• [Journal Article] Severity asses sment of Japanese cedar pollinosis u sing the practical guideline for the management of allergic rhinitis in Japan and the allergic rhinitis and its impact of asthma guideline (2013)
  • Author(s): Gotoh M, Yuta A, Okano M, Ohta N, Matsubara A, Okubo K.
  • Journal Title: Alle rgolgy International Volume: 162 Pages: 181-189
  • DOI: 10.2332/allergolint.12-OA-0498
  • Peer Reviewed
• [Journal Article] Expression of toll-like receptors i n chronic otitis media and cholestea toma (2013)
  • Author(s): Hirai H, Kariya S, Okano M, Fukushim a K, Kataoka Y, Maeda Y, Nishizaki K
  • Journal Title: International Journal of Pedia tric Otorhinolaryngology Volume: 177 Pages: 674-676
  • DOI: 10.1016/j.ijporl
  • Peer Reviewed
• [Journal Article] Characteriza tion of IL-18 expression and release in the pathogenesis of chronic rhin osinusitis (2013)
  • Author(s): Okano M, Fujiwara T, Makihara S, Fuj iwara R, Higaki T, Kariya S, Noda Y, Haruna T, Nishizaki K
  • Journal Title: International Archives o f Allergy and Immunology Volume: 161 Pages: 275-286
  • DOI: 10.1159/000341668
  • Peer Reviewed
• [Journal Article] Neutralizing antibody against granulocyte/macrophage colony-stimulating factorinhibits inflammatory respon seinexperimental otitis media (2013)
  • Author(s): Kariya S, Okano M, Higaki T, Makihar a S, Haruna T, Eguchi M, Nishizaki K
  • Journal Title: Laryngoscope Volume: 123 Pages: 1514-1518
  • DOI: 10.1002/lary.23795
  • Peer Reviewed
• [Presentation] Th2サイトカイン阻害薬の可能性 (2013)
  • Author(s): 岡野光博
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20131128-30
• [Presentation] アレルギー性鼻炎におけるMinimal Persistent Inflammation (2013)
  • Author(s): 岡野光博
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20131128-30
• [Presentation] アレルギー性鼻炎の治療-点鼻ステロイドの利点 (2013)
  • Author(s): 岡野光博
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 20130511-12
• [Book] 風邪症候群のハイリスクグループ.風邪症候群と関連疾患-そのすべてを知ろう (2013)
  • Author(s): 岡野光博(川内秀之編集)
  • Total Pages: 282
  • Publisher: 中山書店
• [Book] 舌下免疫療法の適応と禁忌、舌下免疫療法の実際と対応 (2013)
  • Author(s): 岡野光博(日本鼻下学会報)
  • Total Pages: 22
  • Publisher: 日本鼻科学会
• [Patent(Industrial Property Rights)] IL-10産生促進剤zxs (2013)
  • Inventor(s): 岡野光博
  • Industrial Property Rights Holder: 岡野光博、西崎和則、藤原田鶴子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-189897
  • Filing Date: 2013-09-12
  • Overseas