2013 Fiscal Year Final Research Report
Retinal Ganglion Cell Protection in normal tension glaucoma mouse model by Geranylgeranylacetone
| Project/Area Number |
23592548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAICHI Nobuyoshi 北海道大学, 大学院医学研究科, 客員教授 (00183898)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 眼細胞生物学 / 神経保護 |
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| Research Abstract |
To investigate the cytoprotective effect of geranylgeranylacetone (GGA) on retinal ganglion cell (RGC) degeneration using a normal tension glaucoma (NTG) mouse model, which lacks glutamate/aspartate transporter (GLAST) and demonstrates spontaneous RGC and optic nerve degeneration without elevated intraocular pressure (IOP).The number of RGC of GLAST+/- mice significantly decreased, as compared to that of littermate control mice. RGC loss was suppressed by administration of GGA in a dose-dependent manner. Following GGA administration, HSP70 was significantly up-regulated, and activities of caspase-9 and -3 were suppressed. HSP70 is a favorable target to suppress RGC degeneration, and thus GGA may be applicable for NTG as a promising therapeutics.
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