2013 Fiscal Year Final Research Report
Study of susceptible gene for optic neuritis
| Project/Area Number |
23592554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWAMURA Hiromasa 東京大学, 医学部附属病院, 助教 (70444081)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Fujio 東京大学, 医学部附属病院, 講師 (70154979)
TOKUNAGA Katsushi 東京大学, 大学院医学系研究科, 教授 (40163977)
MABUCHI Akihiko 東京大学, 大学院医学系研究科, 准教授 (80312312)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 眼遺伝学 / 視神経炎 / 疾患感受性遺伝子 / ゲノムワイド関連解析 |
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| Research Abstract |
To examine the susceptible gene for optic neuritis, we collected the clinical data and DNA samples from 73 cases with optic neuritis. We examined SNP types using DNA microarray (Axiom Genome-Wide Human DNA Array) in 51 cases and performed genome wide association analysis to compare with the SNP data of 419 healthy volunteers. Consequently, we found several candidates genes for optic neuritis near the region of short arm in chromosome 2 (C2orf61), short arm in chromosome 4 (RAB28, KCNIP4), short arm in chromosome 9 (GLDC, HAUS6, FAM154A), long arm in chromosome 16 (CBLN1) and short arm in chromosome 17 (CACNG4), that have weak association for optic neuritis.
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Research Products
(20 results)
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[Journal Article] Investigation of the association between Toll-like receptor 9 gene polymorphisms and sarcoidosis in Japanese patients2013
Author(s)
Yotsumoto S, Meguro A, Ishihara M, Uemoto R, Ota M, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
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Journal Title
Ocul Immunol Inflamm
Volume: 21(3)
Pages: 234-6
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[Journal Article] Common variants on chromosome 9p21 are associated with normal tension glaucoma2012
Author(s)
Takamoto M, Kaburaki T, Mabuchi A, Araie M, Amano S, Aihara M, Tomidokoro A, Iwase A, Mabuchi F, Kashiwagi K, Shirato S, Yasuda N, Kawashima H, Nakajima F, Numaga J, Kawamura Y, Sasaki T, Tokunaga K
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Journal Title
PLoS One
Volume: 7(7)
Pages: e40107
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[Journal Article] Genetic characterization and susceptibility for sarcoidosis in Japanese patients : risk factors of BTNL2 gene polymorphisms and HLA class II alleles2012
Author(s)
Suzuki H, Ota M, Meguro A, Katsuyama Y, Kawagoe T, Ishihara M, Asukata Y, Takeuchi M, Ito N, Shibuya E, Nomura E, Uemoto R, Nishide T, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Nakamura J, Saeki K, Ohno S, Inoko H, Mizuki N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53(11)
Pages: 7109-15
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[Journal Article] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population2011
Author(s)
Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
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Journal Title
Mol Vis
Volume: 17
Pages: 731-6
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