2013 Fiscal Year Final Research Report
Roles of Semaphorin in corneal neovascularization
| Project/Area Number |
23592555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
USUI Tomohiko 東京大学, 医学部附属病院, 講師 (80282557)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 角膜 / 血管新生 |
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| Research Abstract |
We investigated the therapeutic potential of semaphorin 3A (SEMA3A) in corneal chemical injury.
Corneal chemical injury was induced in mice by limbal scraping after the application of NaOH. Epithelial wound healing, hemangiogenic, lymphangiogenic responses, and macrophages infiltrations were investigated after administration of SEMA3A or control. The healing of epithelial defects in SEMA3A-treated mice were significantly faster than those of the control mice. The areas of hemangiogenesis and lymphangiogenesis in the animals treated with SEMA3A were significantly decreased as compared to those treated with control treatment. The number of F4/80-positive cells in corneas was significantly lower in mice treated with SEMA3A than in control mice. Our findings demonstrate that exogenous administration of SEMA3A is effective for healing epithelial wounds and inhibiting corneal angiogenesis and inflammation. SEMA3A may have therapeutic potential for preventing blindness.
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