2013 Fiscal Year Final Research Report
Interaction of cell and extracellular matrix structure in the optic nerve head in glaucoma
| Project/Area Number |
23592556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOGANO Tetsuya 新潟大学, 医歯学系, 助教 (70568550)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 緑内障性視神経症 / 視神経乳頭・篩状板 / 光干渉断層計（OCT） / 網膜神経線維層分離所見 / 酸化ストレス、サイトカイン / 視野障害進行速度 / 視野障害の領域 / Quality of Life (QOL) |
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| Research Abstract |
The glaucomatous lamina cribrosa can be observed and measured using Spectral domain Optical Coherence Tomography (SD-OCT). This technique is useful despite some methodological issues and limitations. It may be possible to detect alterations in the lamina cribrosa during the onset and progression of glaucomatous optic neuropathy. Furthermore, Swept source (SS)-OCT can detect the remained macular retinal nerve fiber bundles and their area by a combination with image enhancement software. In more advanced glaucomatous cases, SS-OCT may be more useful to detect or speculate the remained area of central visual field than SD-OCT.
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[Journal Article] Association of HK2 and NCK2 with Normal Tension Glaucoma in the Japanese Population2013
Author(s)
Shi D, Funayama T, Mashima Y, Takano Y, Shimizu A, Yamamoto K, Mengkegale M, Miyazawa A, Yasuda N, Fukuchi T, Abe H, Ideta H, Nishida K, Nakazawa T, Richards JE, Fuse N
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Journal Title
PLOS ONE
Volume: 8(1)
Pages: 1-11
DOI
Peer Reviewed
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[Journal Article] Association of Toll-like Receptor 4 Gene Polymorphisms in Japanese Subjects With Primary Open-Angle, Normal-Tension, and Exfoliation Glaucoma2013
Author(s)
Takano Y, Shi D, Shimizu A, Funayama T, Mashima Y, Yasuda N, Fukuchi T, Abe H, Ideta H, Zheng X, Shiraishi A, Ohashi Y, Nishida K, Nakazawa T, Fuse N
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Journal Title
American Journal of Ophthalmology
Volume: 154(5)
Pages: 825-832
DOI
Peer Reviewed
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[Journal Article] Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population2013
Author(s)
Kato T, Meguro A, Nomura E, Uemoto R, Nomura N, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N
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Journal Title
Eye
Volume: 27
Pages: 1-5
DOI
Peer Reviewed
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[Journal Article] Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma2012
Author(s)
Takano Y, Shi D, Shimizu A, Funayama T, Mashima Y, Yasuda N, Fukuchi T, Abe H, Ideta H, Zheng X, Shiraishi A, Ohashi Y, Nishida K, Nakazawa T, Fuse N
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Journal Title
Am J Ophthalmol
Volume: 154(5)
Pages: 825-832
DOI
Peer Reviewed
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[Journal Article] Investigation of the association between SLC1A3 gene polymorphisms and normal tension glaucoma2011
Author(s)
Yasumura R, Meguro A, Ota M, Nomura E, Uemoto R, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, et al
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Journal Title
Molecular Vision
Volume: 17
Pages: 792-796
URL
Peer Reviewed
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