A study on the role of Tropomyosin gene for cataractogenesis and the prevention of cataract

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592558
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kanazawa Medical University
• Principal Investigator: KUBO Eri 金沢医科大学, 医学部, 教授 (10262619)
• Project Period (FY): 2011 – 2013
• Keywords: トロポミオシン / 白内障 / 後嚢混濁 / 細胞分化 / 上皮間葉系移行

Research Abstract

Tropomyosin is an extracellular matrix protein related with differentiation of lens.Our study revealed that Tpm is related with the onset of human anterior subcapsular cataract and severe nuclear cataract. Further, Tpm was also related with the progression of posterior capsular opacity after cataract, which induces the impaired visual function.
From these results, Tpm may be an important gene related with lens differentiation and epithelial mesenchymal transition.

Research Products

• [Journal Article] Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens (2013)
  • Author(s): Kubo E, Hasanova N, Sasaki H, Singh DP
  • Journal Title: J Cell Mol Med Volume: 17 Pages: 1146-1159
  • Peer Reviewed
• [Journal Article] Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells (2013)
  • Author(s): Kubo E, Hasanova N, Fatma N, Sasaki H, Singh DP
  • Journal Title: Cell Mol Med Volume: 17 Pages: 212-21
  • Peer Reviewed
• [Presentation] 白内障術後の水晶体上皮細胞の変化 (2014)
  • Author(s): 久保江理
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京(東京国際フォーラム、帝国ホテル)
  • Year and Date: 20140402-06
  • Invited
• [Presentation] Tropomyosin : Its relationship with posterior capsule opacity (2014)
  • Author(s): Kubo E, Osada H, Shibata N, Kiyokawa E, Sasaki H, Singh DP
  • Organizer: International Conference of Lens 2014
  • Place of Presentation: Kona (アメリカ合衆国)
  • Year and Date: 20140119-24
• [Presentation] 白内障術後後嚢混濁におけるFGF2およびTGFβ2によるトロポミオシン発現制御機構 (2013)
  • Author(s): 長田ひろみ、ハサノワナイリア、柴田奈保子、清川悦子、佐々木洋、久保江理
  • Organizer: 第52回日本白内障学会総会
  • Place of Presentation: 浦安(シェラトングランデトーキョーベイホテル、ヒルトン東京ベイ)
  • Year and Date: 20130627-29
• [Presentation] FGF2 Antagonizes the TGFβ2-Induced Aberrant Expression of Tropomyosin andα-Smooth Muscle Actin in Mouse and Human Lens Epithelial Cells and Has a Role in Posterior Capsule Opacity (2013)
  • Author(s): Kubo E, Hasanova N, Osada H, Kiyokawa E, Sasaki H, Singh DP
  • Organizer: ARVO 2013 Annual Meeting
  • Place of Presentation: Seattle (アメリカ合衆国)
  • Year and Date: 20130505-09
• [Presentation] 後発白内障モデルを用いた薬物治療の可能性 (2013)
  • Author(s): 久保江理
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 20130404-07
  • Invited
• [Presentation] 後発白内障にみる水晶体の再生と上皮間葉系移(EMT) (2013)
  • Author(s): 久保江理
  • Organizer: 第14回金沢医科大学研究セミナー
  • Place of Presentation: 金沢(金沢医科大学病院本館4階C41講義室)
  • Year and Date: 2013-09-30
• [Presentation] 後発白内障にみる水晶体再生 (2011)
  • Author(s): 久保江理
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 20110512-15
• [Presentation] Aberrant Expression of Tropomyosin Causes Epithelial-Mesenchymal Transition of Lens Epithelial Cells (2011)
  • Author(s): Kubo E, Hasanova N, Singh DP, Takamura Y, Akagi Y
  • Organizer: ARVO 2010 Annual Meeting
  • Place of Presentation: Fort Lauderdale (アメリカ合衆国)
  • Year and Date: 20110501-05
• [Presentation] 白内障予防と治療の可能性 (2011)
  • Author(s): 久保江理
  • Organizer: 第31回金沢医科大学眼科研究会
  • Place of Presentation: 金沢(金沢市アートホール)
  • Year and Date: 2011-11-06