Influence of high fat diet in the retina

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: SHINODA Hajime 慶應義塾大学, 医学部, 講師 (30306766)
• Co-Investigator(Kenkyū-buntansha): OZAWA Yoko 慶應義塾大学, 医学部, 講師 (90265885)
• Project Period (FY): 2011 – 2013
• Keywords: 網膜 / 生活習慣病 / 肥満 / 糖尿病

Research Abstract

Recent increase in the prevalence of metabolic syndrome, which includes vision threatening diseases such as diabetic retinopathy and age-related macular degeneration, is a social issue. Metabolic syndrome includes obesity and high fat diet, which are also known risk factors of diabetic retinopathy and age-related macular degeneration. However, the underlying mechanisms of the relationship between obesity and high fat diet, and retinal diseases were still obscure. In this study, we analyzed the influence of high fat diet in the retina of mice; we evaluated systemic and retinal inflammatory cytokines.

Research Products

• [Journal Article] Ozawa Predictive factors for non-responders to intravitreal ranibizumab treatment in age-related macular degeneration (2014)
  • Author(s): Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Sasaki M, Tsubota K
  • Journal Title: Br J Ophthalmol Pages: 7
  • DOI: 10.1136/bjophthalmol-2013-304670
  • Peer Reviewed
• [Journal Article] Association of Serum Lipids with Macular Thickness and Volume in Type 2 Diabetes without Diabetic Macular Edema (2014)
  • Author(s): Sasaki M, Kawashima M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Jie Jin Wang, Ozawa Y
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55(3) Pages: 1749-53
  • DOI: 10.1167/iovs.13-13035
  • Peer Reviewed
• [Journal Article] Vitrectomy for myopic foveoschisis with internal limiting membrane peeling and no gas tamponade (2013)
  • Author(s): Uchida A, Shinoda H, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y
  • Journal Title: Retina Volume: (Epub ahead of print)
  • DOI: 10.1097/IAE.0b013e3182a0e477
  • Peer Reviewed
• [Journal Article] Ozawa Detection of Early Visual Impairment in Patients with Epiretinal Membrane (2013)
  • Author(s): Nishi Y, Shinoda H, Uchida A, Koto T, Mochimaru H, Nagai N, Tsubota K
  • Journal Title: Acta Ophthalmologica Volume: 91(5) (Epub 2013 Feb 7) Pages: e353-7
  • DOI: 10.1111/aos.12060
  • Peer Reviewed
• [Journal Article] Serum vascular adhesion protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes (2012)
  • Author(s): Yoshikawa N, Noda K, Shinoda H, Uchida A, Ozawa Y, Tsubota K, Mashima Y, Ishida S
  • Journal Title: J Diabetes Complications Volume: 27(2) Pages: 162-6
  • DOI: 10.1016/j.jdiacomp.2012.09.001
  • Peer Reviewed
• [Journal Article] Use of micronutrient supplement for preventing advanced Age-related Macular Degeneration in Japan (2012)
  • Author(s): Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y
  • Journal Title: Archives of Ophthalmology Volume: 130(2) Pages: 254-5
  • DOI: 10.1001/archopthalmol.2011.1368
  • Peer Reviewed
• [Journal Article] Clinical findings in a choroideremia patient who underwent vitrectomy for retinal detachment associated with macular hole (2011)
  • Author(s): Shinoda H, Koto T, Fujiki K, Murakami A, Tsubota K, Ozawa Y
  • Journal Title: Jpn J Ophthalmol Volume: 55(2) Pages: 169-171
  • DOI: 10.1007/s10384-010-0911-0
  • Peer Reviewed
• [Presentation] 狭義加齢黄斑変性に対するpro re nateによるラニビズマブ硝子体注射 (2013)
  • Author(s): 鈴木美砂, 永井紀博, 永井香奈子, 篠田肇, 内田敦郎, 厚東隆志, 持丸博史, 富田洋平, 佐々木真理子, 坪田一男, 小沢洋子
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 神奈川 横浜
  • Year and Date: 20131031-1103
• [Presentation] 抗VEGF療法に反応不良の滲出型加齢黄斑変性に対するアフリベルセプトの作用 (2013)
  • Author(s): 永井紀博, 永井香奈子, 鈴木美砂, 持丸博史, 富田洋平, 内田敦郎, 佐々木真理子, 篠田肇, 坪田一男, 小沢洋子
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 神奈川 横浜
  • Year and Date: 20131031-1103
• [Presentation] Associations of Serum Lipids with Macular Morphology in Patients without Diabetic Macular Edema (2013)
  • Author(s): Sasaki M, Kawashima M, Kawasaki R, Kawai M, Uchida A, Koto T, Mochimaru H, Shinoda H, Jie Jin Wang, Tsubota K, Ozawa Y
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
  • Place of Presentation: Washington State Convention & Trade Center Seattle, USA
  • Year and Date: 20130505-09
• [Presentation] Baseline characteristics and response to intravitreal ranibizumab therapy for age-related macular degeneration (2013)
  • Author(s): Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Tsubota K, Ozawa Y
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
  • Place of Presentation: Washington State Convention & Trade Center Seattle, USA
  • Year and Date: 20130505-09
• [Presentation] 加齢黄斑変性に対するラニビズマブ単独治療における導入期の有効性についての検討 (2012)
  • Author(s): 鈴木美砂、永井紀博、永井香奈子、篠田肇、内田敦郎、厚東隆志、持丸博史、小沢洋子、坪田一男
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20121025-28
• [Presentation] 健常者における黄斑色素密度と血清カロテノイド濃度の相関 (2012)
  • Author(s): 永井紀博, 小林文貴, 永井香奈子, 鈴木美砂, 持丸博史, 内田敦郎, 厚東隆志, 篠田肇, 三宅誠司, 小林沙織, 坪田一男, 小沢洋子
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20121025-28
• [Presentation] 網膜静脈分枝閉塞症に伴う黄斑浮腫に対するベバシズマブテノン嚢下注射の効果の検討 (2012)
  • Author(s): 厚東隆志, 林李恵, 篠田肇, 永井紀博, 内田敦郎, 持丸博史, 坪田一男, 小沢洋子
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20121025-28
• [Presentation] 新規過活動膀胱治療薬ミラベグロン投与後早期に発症した網膜静脈分枝閉塞症の一例 (2012)
  • Author(s): 持丸博史, 前田高宏, 厚東隆志, 内田敦郎, 永井紀博, 篠田肇, 坪田一男, 小沢洋子
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20121025-28
• [Presentation] Associations Between Early Signs Of Age-related Macular Degeneration (AMD) And Risk Of AMD In The Fellow Eye In Patients With Unilateral AMD (2012)
  • Author(s): Sasaki M, Kawasaki R, Uchida A, Koto T, Mochimaru H, Shinoda H, Tien Y. Wong, Tsubota K, Ozawa Y
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
  • Place of Presentation: Fort Lauderdale, U.S.A.
  • Year and Date: 20120506-10
• [Presentation] 片眼加齢黄斑変性患者における前駆病変と僚眼発症の関連 (2012)
  • Author(s): 佐々木真理子, 川崎良, 内田敦郎, 厚東隆志, 持丸博史, 篠田肇, 鈴木美砂, 永井香奈子, 永井紀博, 坪田一男, 小沢洋子
  • Organizer: 第116回日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 20120405-08
• [Presentation] ボリコナゾール内服による視覚障害から視放線の病変が見つかった再生不良性貧血の一例 (2012)
  • Author(s): 堀野武, 内田敦郎, 持丸博史, 厚東隆志, 永井紀博, 篠田肇, 篠田啓, 大出尚郎, 小沢洋子, 坪田一男
  • Organizer: 第116回日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 20120405-08
• [Presentation] 実用視力測定法を用いた特発性網膜上膜術後の視機能変化の評価 (2012)
  • Author(s): 常吉由佳里, 篠田肇, 西恭代, 厚東隆志, 内田敦郎, 永井紀博, 坪田一男, 小沢洋子
  • Organizer: 第35回日本眼科手術学会
  • Place of Presentation: 愛知 名古屋
  • Year and Date: 20120127-29
• [Presentation] 内境界膜剥離併用硝子体手術で中心窩網膜分離が改善したX染色体性若年性網膜分離の1例 (2011)
  • Author(s): 川島弘彦, 篠田肇, 持丸博史, 内田敦郎, 厚東隆志, 永井紀博, 小沢洋子, 坪田一男
  • Organizer: 第50回日本網膜硝子体学会総会
  • Place of Presentation: 東京
  • Year and Date: 20111202-04
• [Presentation] 加齢黄斑変性に対するラニビズマブ治療における無効症例の検討 (2011)
  • Author(s): 鈴木美砂, 佐々木真理子, 厚東隆志, 持丸博史, 内田敦郎, 永井香奈子, 永井紀博, 篠田肇, 坪田一男, 小沢洋子
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 20111007-10
• [Presentation] 視力1.0以上の網膜上膜に対する実用視力測定の有効性 (2011)
  • Author(s): 西恭代, 篠田肇, 結城賢弥, 内田敦郎, 厚東隆志, 小沢洋子, 坪田一男
  • Organizer: 第34回日本眼科手術学会総会
  • Place of Presentation: 京都
  • Year and Date: 20110128-30
• [Remarks]
  • URL: http://www.keio-eye.net/