2013 Fiscal Year Final Research Report
Identification of disease marker for dry eye syndrome by comprehensive analysis of tear components
| Project/Area Number |
23592600
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
|---|
Principal Investigator |
YAMADA Masakazu 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部, 研究員 (50210480)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 蛋白質 / プロテオーム / 分析化学 / 生体分子 / 脂質 |
|---|
| Research Abstract |
This study was undertaken to identify disease-specific marker for dry eye syndrome by comprehensive analysis of tear components. Tear samples were collected by Schirmer test strips. Major tear proteins including secretory IgA, lactoferrin, lipocalin-1, lysozyme and sialic acid, as a marker of secretory mucins, were measured by high performance liquid chromatography. In aqueous deficiency type dry eye, levels of sialic acid in tears of patients were significantly lower than those of normal controls. Treatment with topical application of diquafosol significantly increased sialic acid levels in tears of those patients. In patients with contact lens-induced dry eye, levels of sialic acid in tears were about the same as those of normal controls. Sialic acid in tears may be a good candidate for disease-specific marker for dry eye syndrome, especially for aqueous deficiency type dry eye.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 涙液浸透圧2011
Author(s)
重安千花、山田昌和
Organizer
第65回日本臨床眼科学会
Place of Presentation
東京 (シンポジウム)
Year and Date
2011-10-28
-
