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2013 Fiscal Year Final Research Report

Comprhensive examination for serum autoantigens in endogenous uveitis patients

Research Project

  • PDF
Project/Area Number 23592602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

OHNO Shigeaki  北海道大学, -, 名誉教授 (50002382)

Co-Investigator(Kenkyū-buntansha) ISHIDA Susumu  北海道大学, 大学院研究科, 教授 (10245558)
NAMBA Kenichi  北海道大学, 大学病院, 講師 (70333599)
KITAICHI Nobuyoshi  北海道大学, 医学研究科, 客員准教授 (40431366)
MEGURO Akira  横浜市立大学, 医学研究科, 特任助教 (60508802)
Co-Investigator(Renkei-kenkyūsha) MIZUKI Nobuhisa  横浜市立大学, 医学研究科, 教授 (90336579)
SAWASAKI Tatsuya  愛媛大学, 無細胞生命科学工学研究 センター, 准教授 (50314969)
Project Period (FY) 2011 – 2013
Keywordsぶどう膜炎 / ベーチェット病 / 原田病 / 自己抗体
Research Abstract

In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.
Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.
We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.

  • Research Products

    (56 results)

All 2013 2012 2011

All Journal Article (30 results) (of which Peer Reviewed: 28 results) Presentation (24 results) Book (2 results)

  • [Journal Article] Clinical features of human T lymphotropic virus type-1 associated uveitis in Hokkaido, Japan2013

    • Author(s)
      Kase S, Namba K, Kitaichi N, Iwata D, Ohno S, Ishida S
    • Journal Title

      Jpn J Ophthalmo

      Volume: Vol.57 Pages: 379-384

    • DOI

      10.1007/s10384-013-0244-x

    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease2013

    • Author(s)
      Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Song R, Kang YM, Kang SW, Baek HJ, Kitaichi N, Meguro A, Mizuki N, Namba K, Ishida S, Kim J, Niemczek E, Lee EY, Song YW, Ohno S, Lee EB
    • Journal Title

      Ann Rheum Dis

      Volume: Vol.72 Pages: 1510-1516

    • DOI

      10.1136/annrheumdis-2011-200288

    • Peer Reviewed
  • [Journal Article] Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice2013

    • Author(s)
      Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S, Ishida S
    • Journal Title

      Int J Mol Sci

      Volume: Vol. 14 Pages: 2175-2189

    • DOI

      10.3390/ijms14012175

    • Peer Reviewed
  • [Journal Article] Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease2013

    • Author(s)
      Mizuuchi K, Kitaichi N, Namba K, Horie Y, Ishida S, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: Vol.57 Pages: 245-251

    • DOI

      10.1007/s10384-012-0229-1

    • Peer Reviewed
  • [Journal Article] Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis (TINU) syndrome2013

    • Author(s)
      Takemoto Y, Namba K, Mizuuchi K, Ohno S, Ishida S
    • Journal Title

      Eur J Ophthalmol

      Volume: Vol.23 Pages: 255-257

    • DOI

      10.5301/ejo.5000240

    • Peer Reviewed
  • [Journal Article] Identification of contamination in the American Type Culture Collection stock of human adenovirus type 8 by whole genome sequencing2013

    • Author(s)
      Yamane S, Lee A, Hanaoka N, Gonzalez G, Kaneko H, Ishida S, Kitaichi N, Ohno S, Koyanagi K, Aoki K, Fujimoto T, Yawata N, Watanabe H
    • Journal Title

      J Virol

      Volume: Vol.87 Pages: 1285-1286

    • DOI

      10.1128/JVI.02875-12

    • Peer Reviewed
  • [Journal Article] Reduction of intraocular pressure using a modified 360-degree suture trabeculotomy technique in primary and secondary open-angle glaucoma : A pilot study2012

    • Author(s)
      Chin S, Nitta T, Shinmei Y, Aoyagi M, Nitta A, Ohno S, Ishida S, Yoshida K
    • Journal Title

      J Glaucoma

      Volume: Vol.21 Pages: 401-407

    • DOI

      10.1097/IJG.0b013e318218240c

    • Peer Reviewed
  • [Journal Article] Replication of a microsatellite genome-wide association study of Behcet disease in a Korean population2012

    • Author(s)
      Horie Y, Meguro A, Kitaichi N, Lee E B, Kanda A, Noda K, Song Y W, Park K S, Namba K, Ota M, Inoko H, Mizuki N, Ishida S, Ohno S
    • Journal Title

      Rheumatology

      Volume: Vol. 51

    • DOI

      10.1093/rheumatology/ker444

    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab in a case of occlusive retinal vasculitis accompanied with syphilitic intraocular inflammation2012

    • Author(s)
      Ishijima K, Namba K, Ohno S, Mochizuki K, Ishida S
    • Journal Title

      Case Report Ophthalmol

      Volume: Vol.3 Pages: 434-437

    • DOI

      10.1159/000346046

    • Peer Reviewed
  • [Journal Article] Correlation between elevation of serum antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behcet's disease with infliximab2012

    • Author(s)
      Iwata D, Namba K, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: Vol. 250 Pages: 1081-1087

    • DOI

      10.1007/s00417-011-1908-1

    • Peer Reviewed
  • [Journal Article] Chickenpox chorioretinitis with retinal exudates and periphlebitis2012

    • Author(s)
      Kitamei H, Namba K, Kitaichi N, Wakayama A, Ohno S, Ishida S
    • Journal Title

      Case Report Ophthalmol

      Volume: Vol.3 Pages: 180-184

    • DOI

      10.1159/000339128

    • Peer Reviewed
  • [Journal Article] Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops2012

    • Author(s)
      Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S
    • Journal Title

      Mol Vis

      Volume: Vol.18 Pages: 455-464

    • Peer Reviewed
  • [Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinaseβinhibitor in rats2012

    • Author(s)
      Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S
    • Journal Title

      Mol Vis

      Volume: Vol.18 Pages: 2586-2597

    • Peer Reviewed
  • [Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease2012

    • Author(s)
      Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N
    • Journal Title

      Arch Ophthalmol

      Volume: Vol.130 Pages: 592-598

    • DOI

      10.1001/archophthalmol

    • Peer Reviewed
  • [Journal Article] Astaxanthin increases choroidal blood flow velocity2012

    • Author(s)
      Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: Vol. 250 Pages: 239-245

    • DOI

      10.1007/s00417-011-1843-1

    • Peer Reviewed
  • [Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients2012

    • Author(s)
      Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Mol Vis

      Volume: Vol. 18 Pages: 512-518

    • Peer Reviewed
  • [Journal Article] Genetic characterization and susceptibility for sarcoidosis in Japanese patients : Risk factors of BTNL2 gene polymorphisms and HLA class II alleles2012

    • Author(s)
      Suzuki H, Ota M, Meguro A, Katsuyama Y, Kawagoe T, Ishihara M, Ohno S, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: Vol.53 Pages: 7109-7115

    • DOI

      10.1167/iovs.12-10491

    • Peer Reviewed
  • [Journal Article] 白金-金コロイド標識抗体を用いたアデノウイルス迅速診断検査キットの評価2011

    • Author(s)
      北市伸義、明尾潔、熊埜御堂隆、三島宣彦、三宅瑞絵、大塚宏之、高橋弘毅、溝口晋弘、東真千子、日隈陸太郎、安里良隆、青木功喜、石田晋、大野重昭
    • Journal Title

      医学のあゆみ

      Volume: 237巻 Pages: 214-215

    • Peer Reviewed
  • [Journal Article] Toward an integrated human adenovirus designation system that utilizes molecular and serological data and serves both clinical and fundamental virology2011

    • Author(s)
      Aoki K, Benko M, Davison JA, Echavarria M, Erdman D D, Kitaichi N, Ohno S, 他24名
    • Journal Title

      J Viol

      Volume: Vol.85 Pages: 5703-5704

    • DOI

      10.1128/JVI.00491-11

    • Peer Reviewed
  • [Journal Article] Clinical features of adenoviral conjunctivitis at the early stage of infection2011

    • Author(s)
      Aoki K, Kaneko H, Kitaichi N, Ohguchi T, Tagawa Y, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: Vol. 55 Pages: 11-15

    • DOI

      10.1007/s10384-010-0894-x

    • Peer Reviewed
  • [Journal Article] Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease2011

    • Author(s)
      Horie Y, Saito W, Kitaichi N, Miura T, Ishida S, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: Vol. 55 Pages: 57-61

    • DOI

      10.1007/s10384-010-0887-9

    • Peer Reviewed
  • [Journal Article] Investigation of association between TLR9 gene polymorphisms and VKH in Japanese patients2011

    • Author(s)
      Ito R, Ota M, Meguro A, Katsuyama Y, Uemoto R, Nomura E, Nishide T, Kitaichi N, Horie Y, Namba K, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Ocul Immunol Inflamm

      Volume: Vol.19 Pages: 202-205

    • DOI

      10.3109/09273948.2011.553981

    • Peer Reviewed
  • [Journal Article] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan2011

    • Author(s)
      Jin XH, Aoki K, Kitaichi N, Ariga T, Ishida S, Ohno S
    • Journal Title

      Mol Vis

      Volume: Vol.17 Pages: 3121-3127

    • Peer Reviewed
  • [Journal Article] Detection of human adenovirus hexon antigen using carbon nanotube sensors2011

    • Author(s)
      Jin XH, Ishii A, Aoki K, Ishida S, Mukasa K, Ohno S
    • Journal Title

      J Virol Methods

      Volume: Vol.171 Pages: 405-407

    • DOI

      10.1016/j.jviromet.2010.12.004

    • Peer Reviewed
  • [Journal Article] Recombination analysis of intermediate human adenovirus type 53 in Japan by complete genomesequence2011

    • Author(s)
      Kaneko H, Aoki K, Ishida S, Ohno S, Kitaichi N, Ishiko H, Fujimoto T, Ikeda Y, Nakamura M, Gonzalez G, Koyanagi KO, Watanabe H, Suzutani T
    • Journal Title

      J Gen Virol

      Volume: Vol. 92 Pages: 1251-1259

    • DOI

      10.1099/vir.0.030361-0

    • Peer Reviewed
  • [Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan2011

    • Author(s)
      Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S
    • Journal Title

      Br J Ophthalmol

      Volume: Vol. 95 Pages: 32-36

    • DOI

      10.1136/bjo.2009.178772

    • Peer Reviewed
  • [Journal Article] Diffuse infiltrating retinoblastoma invading subarachnoid space2011

    • Author(s)
      Kase S, Yoshida K, Suzuki S, Ohshima KI, Ohno S, Ishida S
    • Journal Title

      Clin Ophthalmol

      Volume: Vol. 5 Pages: 861-863

    • DOI

      10.2147/OPTH.S20913

  • [Journal Article] Association analysis of toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese patients2011

    • Author(s)
      Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Hum Immunol

      Volume: Vol. 72 Pages: 269-272

    • DOI

      10.1016/j.humimm.2010.12.007

  • [Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population2011

    • Author(s)
      Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Mol Vis

      Volume: Vol. 17 Pages: 731-736

    • Peer Reviewed
  • [Journal Article] Japanese guideline for allergic con junctival diseases2011

    • Author(s)
      Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H
    • Journal Title

      Allergol Int

      Volume: Vol.60 Pages: 191-203

    • DOI

      10.2332/allergolint.11-RAI-0335

    • Peer Reviewed
  • [Presentation] Clinical features of Vogt-Koyanagi-Harada's disease2013

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      7th Korean Uveitis Conference
    • Place of Presentation
      Seoul, Korea, Seoul National University
    • Year and Date
      2013-11-23
  • [Presentation] Disease mechanisms and tretment of Behcet's disease2013

    • Author(s)
      Ohno S
    • Organizer
      14th Behcet's Disease
    • Place of Presentation
      Seoul, Korea, Seoul National University
    • Year and Date
      2013-11-22
  • [Presentation] Management dilemmas in uveitis2012

    • Author(s)
      Ohno S, Chin S
    • Organizer
      Second Biennial National Conference
    • Place of Presentation
      Bangladesh Uvea Society, Dhaka, Bang ladesh
    • Year and Date
      2012-12-15
  • [Presentation] Presentation perspectives in Vogt-Koyanagi-Harada disease2012

    • Author(s)
      Ohno S
    • Organizer
      Second Biennial National Conference
    • Place of Presentation
      Bangladesh Uvea Society, Dhaka, Bangladesh
    • Year and Date
      2012-12-15
  • [Presentation] Corticosteroid therapy in uveitis2012

    • Author(s)
      Ohno S
    • Organizer
      Ophthalmology Seminar
    • Place of Presentation
      Thimpu National Referral Hospital, Thimpu, Bhutan
    • Year and Date
      2012-12-12
  • [Presentation] Management of second ry glaucoma in uveitis2012

    • Author(s)
      Ohno S, Chin S
    • Organizer
      Ophthalmology Seminar
    • Place of Presentation
      Thimpu National Referral Hospital : Thimpu, Bhutan
    • Year and Date
      2012-12-12
  • [Presentation] From autoimmunity to autoinf lammation in the immunopathogenesis of Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      2012 Seoul National University-Hokkaido University Joint Symposium in Ophthalmology
    • Place of Presentation
      Sapporo(Hokkaido University), Japan
    • Year and Date
      2012-10-19
  • [Presentation] Epidemiology and genetics of Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      Bechet's Disease Symposium; How to differentiate Behcet's disease from other types of uveitis
    • Place of Presentation
      Sani(Sani Beach Resort), Greece
    • Year and Date
      2012-10-19
  • [Presentation] Silk route disease : epidemio logy and genetics2012

    • Author(s)
      Ohno S
    • Organizer
      International meeting of collaborative studies on Behcet's disease and other uveitis entities
    • Place of Presentation
      Rome(ローマ大学), Italy
    • Year and Date
      2012-10-16
  • [Presentation] Anti-TNFαtherapy for intractable uveoreti nitis in Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      Yokohama(パシフィコ横浜), Japan
    • Year and Date
      2012-07-14
  • [Presentation] Diagnosis and treatment of a llergic conjuctivitis2012

    • Author(s)
      Ohno S
    • Organizer
      16th Afro Asian Congress of Ophthal mology
    • Place of Presentation
      Istanabul(HARBIYE MILITARY MUSEUM), Turkey
    • Year and Date
      2012-06-15
  • [Presentation] Ocular lesions in Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      16th Afro Asian Congress of Ophthalmology
    • Place of Presentation
      Istanabul(HARBIYE MILITARY MUSEUM), Turkey
    • Year and Date
      2012-06-13
  • [Presentation] Epidemiology of allergic con junctival diseases in Japan2012

    • Author(s)
      Ohno S
    • Organizer
      1st Conference on the Tear Film and Ocular Surface in Asia
    • Place of Presentation
      Kamakura(Kenchoji), Japan
    • Year and Date
      2012-04-04
  • [Presentation] Treatment of Behcet's disease with infliximab.3rd Japan-Korea Symposium on Behcet's Disease2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Mizuki N
    • Organizer
      Behcet's Disease Study Group, Ministry of Health. Labour and Welfare, Japan
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-16
  • [Presentation] Infliximab therapy of Behcet's disease2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Mizuki N
    • Organizer
      3rd International Uveitis Symposium
    • Place of Presentation
      重慶カールトンホテル(中国)
    • Year and Date
      2011-12-02
  • [Presentation] Molecular genetics of uveitis2011

    • Author(s)
      Ohno S, Mizuki N
    • Organizer
      International Symposium on Recent Trends in Uveitis
    • Place of Presentation
      LV Prasad Eye Institue (India)
    • Year and Date
      2011-11-18
  • [Presentation] Corticosteroid therapy of uveitis and intraocular inflammation2011

    • Author(s)
      Ohno S, Namba K
    • Organizer
      International Symposium on Recent Trends in Uveitis
    • Place of Presentation
      LV Prasad Eye Institue (India)
    • Year and Date
      2011-11-18
  • [Presentation] Epidemiology of Behcet's disease. Session; Behcet's Disease : An Update and Future Prospects2011

    • Author(s)
      Ohno S, Kitaichi N, Meguro A, Mizuki N, Isogai E
    • Organizer
      11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-15
  • [Presentation] Update of anti-TNF alpha therapy in Behcet's disease2011

    • Author(s)
      Ohno S, Namba K, Iwata D, Kitaichi N, Mizuki N
    • Organizer
      Italian Society of Uveitis and Inflammatory Ocular Diseases, (SIUMIO) / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-15
  • [Presentation] Introduction, Conclusions and Future, Workshop on Epidemiology and Diagnosis of Behcet's Disease2011

    • Author(s)
      Ohno S
    • Organizer
      First Workshop of (IOBDSG) / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
  • [Presentation] Panel Discussion with Chee SP, Goto H, Rao NA, Future studies and conclusions2011

    • Author(s)
      Ohno S, Panel Discussion with Chee SP, Goto H, Rao NA
    • Organizer
      The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
  • [Presentation] Trabecular depigmentation in convalescent stage of VKH disease2011

    • Author(s)
      Ohno S, Mizuuchi K, Namba K, Kitaichi N, Horie Y
    • Organizer
      The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
  • [Presentation] Classification and diagnostic criteria for Behcet's disease2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
  • [Presentation] Managing ocular manifestations of systemic diseases with local therapy : Is it possible?2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-13
  • [Book] 小児感染症学2011

    • Author(s)
      北市伸義, 大野重昭
    • Total Pages
      396
    • Publisher
      診断と治療社
  • [Book] 治療薬ハンドブック20112011

    • Author(s)
      北市伸義, 大野重昭
    • Total Pages
      1427
    • Publisher
      じほう

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Published: 2015-07-16  

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