2013 Fiscal Year Final Research Report
Comprhensive examination for serum autoantigens in endogenous uveitis patients
| Project/Area Number |
23592602
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Susumu 北海道大学, 大学院研究科, 教授 (10245558)
NAMBA Kenichi 北海道大学, 大学病院, 講師 (70333599)
KITAICHI Nobuyoshi 北海道大学, 医学研究科, 客員准教授 (40431366)
MEGURO Akira 横浜市立大学, 医学研究科, 特任助教 (60508802)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
SAWASAKI Tatsuya 愛媛大学, 無細胞生命科学工学研究 センター, 准教授 (50314969)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ぶどう膜炎 / ベーチェット病 / 原田病 / 自己抗体 |
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| Research Abstract |
In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.
Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.
We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.
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[Journal Article] Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease2013
Author(s)
Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Song R, Kang YM, Kang SW, Baek HJ, Kitaichi N, Meguro A, Mizuki N, Namba K, Ishida S, Kim J, Niemczek E, Lee EY, Song YW, Ohno S, Lee EB
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Journal Title
Ann Rheum Dis
Volume: Vol.72
Pages: 1510-1516
DOI
Peer Reviewed
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[Journal Article] Identification of contamination in the American Type Culture Collection stock of human adenovirus type 8 by whole genome sequencing2013
Author(s)
Yamane S, Lee A, Hanaoka N, Gonzalez G, Kaneko H, Ishida S, Kitaichi N, Ohno S, Koyanagi K, Aoki K, Fujimoto T, Yawata N, Watanabe H
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Journal Title
J Virol
Volume: Vol.87
Pages: 1285-1286
DOI
Peer Reviewed
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[Journal Article] Replication of a microsatellite genome-wide association study of Behcet disease in a Korean population2012
Author(s)
Horie Y, Meguro A, Kitaichi N, Lee E B, Kanda A, Noda K, Song Y W, Park K S, Namba K, Ota M, Inoko H, Mizuki N, Ishida S, Ohno S
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Journal Title
Rheumatology
Volume: Vol. 51
DOI
Peer Reviewed
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[Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinaseβinhibitor in rats2012
Author(s)
Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S
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Journal Title
Mol Vis
Volume: Vol.18
Pages: 2586-2597
Peer Reviewed
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[Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease2012
Author(s)
Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N
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Journal Title
Arch Ophthalmol
Volume: Vol.130
Pages: 592-598
DOI
Peer Reviewed
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[Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients2012
Author(s)
Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N
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Journal Title
Mol Vis
Volume: Vol. 18
Pages: 512-518
Peer Reviewed
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[Journal Article] Investigation of association between TLR9 gene polymorphisms and VKH in Japanese patients2011
Author(s)
Ito R, Ota M, Meguro A, Katsuyama Y, Uemoto R, Nomura E, Nishide T, Kitaichi N, Horie Y, Namba K, Ohno S, Inoko H, Mizuki N
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Journal Title
Ocul Immunol Inflamm
Volume: Vol.19
Pages: 202-205
DOI
Peer Reviewed
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[Journal Article] Recombination analysis of intermediate human adenovirus type 53 in Japan by complete genomesequence2011
Author(s)
Kaneko H, Aoki K, Ishida S, Ohno S, Kitaichi N, Ishiko H, Fujimoto T, Ikeda Y, Nakamura M, Gonzalez G, Koyanagi KO, Watanabe H, Suzutani T
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Journal Title
J Gen Virol
Volume: Vol. 92
Pages: 1251-1259
DOI
Peer Reviewed
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[Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan2011
Author(s)
Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S
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Journal Title
Br J Ophthalmol
Volume: Vol. 95
Pages: 32-36
DOI
Peer Reviewed
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[Journal Article] Association analysis of toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese patients2011
Author(s)
Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N
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Journal Title
Hum Immunol
Volume: Vol. 72
Pages: 269-272
DOI
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[Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population2011
Author(s)
Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
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Journal Title
Mol Vis
Volume: Vol. 17
Pages: 731-736
Peer Reviewed
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[Journal Article] Japanese guideline for allergic con junctival diseases2011
Author(s)
Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H
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Journal Title
Allergol Int
Volume: Vol.60
Pages: 191-203
DOI
Peer Reviewed
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[Presentation] Update of anti-TNF alpha therapy in Behcet's disease2011
Author(s)
Ohno S, Namba K, Iwata D, Kitaichi N, Mizuki N
Organizer
Italian Society of Uveitis and Inflammatory Ocular Diseases, (SIUMIO) / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
Place of Presentation
Hotel Taj Exotica (India)
Year and Date
2011-11-15
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