2013 Fiscal Year Final Research Report
Establishment of new concepts in cone electroretinogram using transgenic rabbits
| Project/Area Number |
23592603
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Mie University |
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Principal Investigator |
KONDO MINEO 三重大学, 医学(系)研究科(研究院), 教授 (80303642)
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| Co-Investigator(Kenkyū-buntansha) |
TERASAKI Hiroko 名古屋大学, 医学(系)研究科(研究院), 教授 (40207478)
KACHI Shu 名古屋大学, 医学部附属病院, 講師 (30345904)
KOMEIMA Keiichi 名古屋大学, 医学部附属病院, 講師 (40362256)
UENO Shinji 名古屋大学, 医学(系)研究科(研究院), 助教 (80528670)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 網膜色素変性 / 網膜電図 / 動物モデル / トランスジェニック |
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| Research Abstract |
The purpose of this study was to determine the contributions of cones and post- photoreceptoral neurons to the a-wave of the photopic ERGs in rhodopsin Pro347Leu transgenic (Tg) rabbits. Post-photoreceptral neural function was completely suppressed by intravitreal injections of CNQX and APB. We found that the percentage contribution of the cone photoreceptorsto the photopic ERG a-waves ranged from 54% to 75% in wild-type (WT) rabbits. In contrast, the percentage contribution of the cone photoreceptors in Tg rabbits ranged from 32% to 51%. These results suggest that the relative contribution of cone photoreceptors to the photopic ERG a-wave is smaller in retinas with inherited photoreceptor degeneration.
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[Journal Article] Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy2013
Author(s)
Ueno S, Nishiguchi KM, Tanioka H, Enomoto A, Yamanouchi T, Kondo M, Yasuma TR, Yasuda S, Kuno N, Takahashi M, Terasaki H
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Journal Title
PLoS One
Volume: 8 (eCollection 2013)
Pages: e81507
DOI
Peer Reviewed
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[Journal Article] Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene2013
Author(s)
Nishiguchi KM, Tearle RG, Liu YP, Oh EC, Miyake N, Benaglio P, Harper S, Koskiniemi-Kuendig H, Venturini G, Sharon D, Koenekoop RK, Nakamura M, Kondo M, Ueno S, Yasuma TR, Beckmann JS, Ikegawa S, Matsumoto N, Terasaki H, Berson EL, Katsanis N, Rivolta C
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110
Pages: 16139-16144
DOI
Peer Reviewed
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[Journal Article] Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration2013
Author(s)
Fukuda S, Nagano M, Yamashita T, Kimura K, Tsuboi I, Salazar G, Ueno S, Kondo M, Kunath T, Oshika T, Ohneda O
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Journal Title
Stem Cells
Volume: 31
Pages: 2149-2161
DOI
Peer Reviewed
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[Journal Article] Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography2012
Author(s)
Muraoka Y, Ikeda HO, Nakano N, Hangai M, Toda Y, Okamoto-Furuta K, Kohda H, Kondo M, Terasaki H, Kakizuka A, Yoshimura N
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Journal Title
PLoS One
Volume: 7
Pages: e36135
DOI
Peer Reviewed
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[Journal Article] Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells2012
Author(s)
Omori Y, Araki F, Chaya T, Kajimura N, Irie S, Terada K, Muranishi Y, Tsujii T, Ueno S, Koyasu T, Tamaki Y, Kondo M, Amano S, Furukawa T
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Journal Title
J Neurosci
Volume: 32(18)
Pages: 6126-6237
DOI
Peer Reviewed
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[Journal Article] Two novel mutations in the EYS gene are possible major causes of autosomal recessive retinitis pigmentosa in the Japanese population2012
Author(s)
Hosono K, Ishigami C, Takahashi M, Park DH, Hirami Y, Nakanishi H, Ueno S, Yokoi T, Hikoya A, Fujita T, Zhao Y, Nishina S, Shin JP, Kim IT, Yamamoto S, Azuma N, Terasaki H, Sato M, Kondo M, Minoshima S, Hotta Y
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Journal Title
PLoS One
Volume: 7
Pages: e31036
DOI
Peer Reviewed
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[Journal Article] Short-interfering RNAs induce retinal degeneration via TLR3 and IRF32012
Author(s)
Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J
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Journal Title
Mol Ther
Volume: 20
Pages: 101-108
DOI
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[Journal Article] miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression2011
Author(s)
Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Chérasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T
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Journal Title
Nat Neurosci
Volume: 14
Pages: 1125-1134
DOI
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[Journal Article] Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011
Author(s)
Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T
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Journal Title
PLoS One
Volume: 6
Pages: e19911
DOI
Peer Reviewed
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[Journal Article] Clinical Phenotype in Ten Unrelated Japanese Patients with Mutations in the EYS Gene
Author(s)
Suto K, Hosono K, Takahashi M, Hirami Y, Arai Y, Nagase Y, Ueno S, Terasaki H, Minoshima S, Kondo M, Hotta Y
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Journal Title
Jpn J Ophthalmol
Volume: (in press)
Peer Reviewed
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[Presentation] Identification of autoanti- bodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011
Author(s)
Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T
Organizer
Annual Meeting of the Association for Research in Vision and Ophthalmology
Place of Presentation
Florida, USA
Year and Date
2011-05-03
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