2013 Fiscal Year Final Research Report
Molecular function of Trim16 in wound healing
| Project/Area Number |
23592641
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ADACHI Koji 筑波大学, 医学医療系, 講師 (70572569)
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| Co-Investigator(Kenkyū-buntansha) |
WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612)
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 創傷治癒学 / 酸化ストレス |
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| Research Abstract |
Though Trim16 is known to be expressed in epidermal tissue, and involved in KGF signaling, the precise molecular function is unknown. In this study, we analyzed the role of Trim16 in sunburn formation by UVB irradiation on skin. We found that deficiency in Trim16 leads to high sensitivity to UVB by using Trim16 knock down cells and knockout mouse. Our data suggested decrease in the anti-apoptotic protein level is related to this phenomenon, Trim16 has a role in regulation of apoptosis pathway.
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