2013 Fiscal Year Final Research Report
| Project/Area Number |
23592646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
NAITOH Motoko 京都大学, 医学(系)研究科(研究院), 講師 (30378723)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ケロイド / HtrA1 / マトリックス / リモデリング / セリンプロテアーゼ |
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| Research Abstract |
Keloids are a dermal fibrotic disease whose etiology remains unknown.
To clarify the molecular mechanism of keloid pathogenesis, we focused on HtrA1, a serine protease-family protein to investigated roles of this protein in keloid pathogenesis. HtrA1 and whose substrate, Fibronectin were over-expressed in the keloid lesions, and fragmentation of Fibronectin was observed in keloid lesions. Knockdown of HtrA1 in keloid-derived fibroblasts lead to reduce cell prolifaration rate. Thus, HtrA1 may promote keloid development through matrix degradation
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