2013 Fiscal Year Final Research Report
The development of new treatments for the flap survial and wound healing using fibrocyte or relevant stem cells.
| Project/Area Number |
23592649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKITA Sadanori 長崎大学病院, 形成外科, 講師 (90315250)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHIDA Kenji 長崎医療センター, 形成外科, 医師 (50599933)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 幹細胞 / 創傷治癒 / リンパ浮腫動物モデル / 虚血肢動物モデル |
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| Research Abstract |
We have developed two new animal models of a lower extremity lymphedema mouse model and a lower extremity limb ischemia rat model. In the lymphedema model we confirmed regeneration of lymphatic vessels in the lymphedema model using adipose-derived stem cell transplantation. In the limb ischemia model we confirmed the improvement of blood circulation. We found to further improve blood circulation using combined adipose-derived stem cells and flap transplantation.
We think our two new animal models are available for the development of novel therapies using various stem cells and drug agents.
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[Journal Article] One-stage simultaneous skin grafting with artificial dermis and basic fi broblast growth factor successfully improves elasticity with maturation of scar formation2013
Author(s)
Hamuy R, Kinoshita N, Yoshimoto H, H ayashida K, Houbara S, Nakashima M, Suzuki K, Mitsutake N, Mussazhanova Z, Kashiyama K, Hirano A, Akita S
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Journal Title
Repair and Regene
Volume: 21(1)
Pages: 141-154
Peer Reviewed
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