2013 Fiscal Year Final Research Report
Development of MAIR-I (CD300a) as a molecular target of sepsis treatment
| Project/Area Number |
23592664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | MAIR-I / 敗血症 / アポトーシス細胞 / フォスファチジルセリン / 肥満細胞 / サイトカイン / CD300a |
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| Research Abstract |
We identified that the immunoreceptor MAIR-I (CD300a), which is expressed on myeloid cells including mast cells, is a phosphatidylserine (PS) receptor. We showed that MAIR-I does not facilitate macrophage phagocytosis of apoptotic cells, but rather inhibits the production of inflammatory cytokines and chemokines from mast cells that to recruit neutrophils to the peritoneal cavity to clear bacteria during murine sepsis model. We showed MAIR-I on mast cells and PS binding contributes to the survival of murine sepsis model.
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[Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor2012
Author(s)
Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A
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Journal Title
J Exp Med
Volume: 209(8)
Pages: 1493-1503
DOI
Peer Reviewed
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[Journal Article] The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses2011
Author(s)
Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Nadia K. Tchao, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lewis L. Lanier, Shibuya A
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Journal Title
J Exp Med
Volume: 208(8)
Pages: 1661-1671
DOI
Peer Reviewed
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