2014 Fiscal Year Final Research Report
Resarch for the cellular effects of a Sarin-like organophospherous agent through cytoskeletons.
| Project/Area Number |
23592669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Hiroshima Cosmopolitan University (2012-2014)
Hiroshima University (2011) |
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Principal Investigator |
MAKITA Ryosuke 広島都市学園大学, 健康科学部, 准教授 (20321812)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Masataka 広島大学, 医歯薬学総合研究科, 教授 (80227991)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 神経剤 / 法医学 / 救急医学 |
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| Outline of Final Research Achievements |
To determine cellular mechanisms of poisoning by organophosperous agents Sarin and Soman, we analyzed effects of BIMP to culture cell-lines from human nervous system. By immunocytochemistry and Western-blotting, we obtained results that BIMP destabilized polymerization of cytoskeletons of the cells. However, the results were instable itself; we failed to obtain repeatability of the results between our experiences.
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| Free Research Field |
医歯薬学
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