2013 Fiscal Year Final Research Report
Effects of Newly synthetized antioxydant DHLHZn on Bleomycine induced pulmonary fibrosis
| Project/Area Number |
23592673
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUSAKA Junya 大分大学, 医学部, 客員研究員 (00567951)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 肺線維症 / ブレオマイシン / 抗酸化作用 / α-リポ酸誘導体 |
|---|
| Research Abstract |
This study investigated the reduction in acute pulmonary fibrosis after Sodium Zinc Histidine Dithiooctanamide (DHL-HisZn) which was the zinc chelate of the alpha-lipoic acid derivative of the de novo synthesis, to inhibit oxidative stress induced by bleomycin in a rat model. After the administration of bleomycin, the animals were sacrificed and lung and serum samples were harvested and evaluated. This study results indicate that treatment with DHL-HisZn can alleviate pulmonary fibrosis in a model of bleomycin.
|
