2013 Fiscal Year Final Research Report
Intercellular odontoblast-neuron communication to drive sensory transduction and mineralization sequences via ATP-permeable channel
| Project/Area Number |
23592751
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Tokyo Dental College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIMURA Maki 東京歯科大学, 歯学部, 客員講師 (90582346)
SATO Masaki 東京歯科大学, 生理学講座, 助手 (80598855)
SOBHAN Ubaidus 東京歯科大学, 生理学講座, 非常勤講師 (90598856)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 歯学 / シグナル伝達 / 神経科学 / 象牙芽細胞 / 細胞間コミュニケーション / 神経伝達 / 痛覚 / 歯内療法学 |
|---|
| Research Abstract |
Mechanical-, thermal-, and chemical-stimuli to the surface of exposed dentin induce dentinal pain. However, mechanisms understanding dentinal pain remain to be clarified. We examined intercellular communication between odontoblasts and trigeminal ganglion (TG) neurons during direct mechanical stimulation of odontoblasts. The results showed that ATP released from mechanically stimulated odontoblasts via pannexin-1 in response to activation of mechano-sensitive transient receptor potential channels acts as neurotransmitter, to transduce a sensory signal to TG neurons by activation of ATP receptors. We suggest that odontoblasts are sensory receptor cells to drive sensory transduction sequence for dentinal pain.
|
-
-
-
-
-
-
-
-
-
[Journal Article] Hypotonic-induced stretching of plasma membrane activates transient receptor potential vanilloid channels and sodium-calcium exchangers in mouse odontoblasts2013
Author(s)
M Sato, U Sobhan, M Tsumura, H Kuroda, M Soya, A Masamura, A Nishiyama, A Katakura, T Ichinohe, M Tazaki, Y Shibukawa
-
Journal Title
Journal of Endodontics
Volume: 39
Pages: 779-787
DOI
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] T Ichinohe,Search for expression of Na^+-Ca^<2+> exchangers in rat trigeminal ganglion2012
Author(s)
H Kuroda, Y Shibukawa, A Masamura, M Soya, M Sato, U Sobhan, M Tsumura, M Tazaki, T Ichinohe
Organizer
89th Annual Meting for the physiological society of Japan
Place of Presentation
Matsumoto, Nagano
Year and Date
20120329-31
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] 澁川義幸,歯痛の臨床的解釈,Q & A,DENTAL DIAMOND, 38, 118-119, 2013
-
[Remarks] 澁川義幸、田﨑雅和,歯科医学の古きをたずねて新しきを知る第3回:象牙質知覚過敏症, 日本歯科評論,73:143-145,2013
-
[Remarks] 佐藤正樹、隝田みゆき、津村麻記、Sobhan Ubaidus、澁川義幸,歯科医学の古きをたずねて新しきを知る第2回:歯内療法薬剤の作用機序,日本歯科評論,73:149-151,2013
-
[Remarks] 澁川義幸,歯科医学の歯科医学の古きをたずねて新しきを知る(第一回):象牙質の痛み,日本歯科評論,73:155-157,2013
-
[Remarks] 澁川義幸,市川秀樹,Sobhan Ubaidus,津村麻記,佐藤正樹,田崎雅和,歯髄・象牙質感覚の基礎と臨床,日本歯科医師会雑誌,65,21-30,2012
-
[Remarks] 澁川義幸,食育を理解するための味覚の基礎,東京都学校歯科医会会誌,75号:11-17,2012
-
[Remarks] 澁川義幸,激辛が歯痛の特効薬になるかもしれない−味覚と歯痛の基礎,第568回東京歯科大学理工懇談会例会,平成24年 9月21日,東京都
-
[Remarks] 澁川義幸,歯が痛い!痛いのは歯だけ?千葉市民文化大学健康医学科,2011年7月27日,千葉市
-
[Remarks] 澁川義幸,口腔内体性感覚の特殊性,株式会社花王研究講演会,2012年10月23日, 東京都
