A novel visualization approach on a 64-row multidetector CT perfusion in the early detection of subclinical cervical lymph node metastases

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Niigata University
• Principal Investigator: HAYASHI Takafumi 新潟大学, 医歯学系, 教授 (80198845)
• Co-Investigator(Renkei-kenkyūsha): SAKU Takashi 新潟大学, 医歯学系, 教授 (40145264)
• Research Collaborator: SHIMIZU Satoshi ザイオソフト株式会社, マーケティング部, 部長
• Project Period (FY): 2011 – 2013
• Keywords: CT perfusion / 口腔癌 / 頸部リンパ節転移 / 灌流速度 / 造影CT / ダイナミックCT

Research Abstract

We estimated the clinical utility of the CT perfusion in the early detection of subclinical lymph node metastases in six patients with oral cancer. CT perfusion examination was performed using a 64-row multidetector CT scanner and the perfusion parameters (single compartment kinetic model: SC Flow, deconvolution method: BF, BV and MTT) were calculated with dedicated software (ziostation2). Clinically negative eight lymph nodes with a minimal diameter of 10 mm or less were enrolled in this study and seven of them were proved to be metastatic by histopathological examination. Among with the above-mentioned parameters, SC flow value of three metastatic nodes showed a 50 % decrease compared to that of the benign contralateral lymph nodes in the same neck level. We deemed that this "hypoperfusion" phenomenon might be one of the novel diagnostic criteria in the small metastatic lymph nodes without known evidence of metastases on the CT perfusion study.

Research Products

• [Journal Article] Detection of subsequent cervical lymph node metastasis in a patient with gingival carcinoma using computed tomography perfusion with a single-compartment kinetic model (2014)
  • Author(s): Hayashi T, Tanaka R, Yamazaki M, Cheng J, Oda Y, Hayashi H, Takeishi E, Honma K, Nishiyama H
  • Journal Title: Oral Radio Volume: 30(2) Pages: 186-191
  • DOI: 10.1007/s11282-013-0153-1
  • Peer Reviewed
• [Presentation] 口腔癌頸部リンパ節転移診断におけるCT灌流画像の応用―deconvolution法とsingle compartment法との比較― (2013)
  • Author(s): 林孝文,新垣元基,曽我麻里恵,池真樹子,新國農,小山純市,田中礼,勝良剛詞,西山秀昌
  • Organizer: PO法人日本歯放射線学会第18回臨床画像大会および教育研修会
  • Place of Presentation: 東京(東京歯科大学水道橋校舎)
  • Year and Date: 20131101-03
• [Presentation] Clinical significance of CT perfusion in assessing the subsequent lymph node metastases in patients with oral cancer (2013)
  • Author(s): Hayashi T, Ike M, Nikkuni Y, Koyama J, Tanaka R, Katsura K, Nishiyama H
  • Organizer: The 19th International Congress of Dento-Maxillo-Facial Radiology
  • Place of Presentation: Bergen, Norway (Grieghallen)
  • Year and Date: 20130622-27
• [Presentation] 頸部リンパ節転移診断へのCT perfusionの応用 (2013)
  • Author(s): 林孝文,新國農,小林正治,児玉泰光,勝良剛詞
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 20130613-14
• [Presentation] 口腔癌頸部リンパ節転移診断におけるCT perfusionの応用 (2013)
  • Author(s): 林孝文,新垣元基,曽我麻里恵,池真樹子,新國農,小山純市,田中礼,勝良剛詞,西山秀昌
  • Organizer: 第113回新潟臨床放射線学会
  • Place of Presentation: 新潟市(新潟大学医学部)
  • Year and Date: 2013-12-14
• [Presentation] CT perfusionとUS elastographyにより後発頸部リンパ節転移を評価した舌癌の1例 (2012)
  • Author(s): 林孝文
  • Organizer: 第31回日本画像医学会
  • Place of Presentation: 東京(東京ステーションコンファレンス)
  • Year and Date: 20120217-18
• [Presentation] 後発頸部リンパ節転移をCT perfusionとUS elastographyを用いて評価した舌癌の1例 (2012)
  • Author(s): 林孝文,斎藤美紀子,勝良剛詞,山崎学,丸山智,芳澤享子,小林正治
  • Organizer: 第30回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: さいたま市(大宮ソニックシティー)
  • Year and Date: 20120126-27
• [Presentation] 潜在的頸部リンパ節転移へのCT perfusionの応用 (2012)
  • Author(s): 林孝文,池真樹子,新国農,斎藤美紀子,小山純市,田中礼,勝良剛詞,西山秀昌
  • Organizer: 第53回日本歯科放射線学会学術大会
  • Place of Presentation: 盛岡市(岩手県民情報交流センター)
  • Year and Date: 2012-06-02
• [Presentation] CT perfusionとelastographyを用いて後発頸部リンパ節転移を評価した舌癌の1例 (2011)
  • Author(s): 林孝文,池真樹子,新国農,斎藤美紀子,小山純市,田中礼,勝良剛詞,西山秀昌,山崎学,丸山智,芳澤享子,小林正治
  • Organizer: 第109回新潟臨床放射線学会
  • Place of Presentation: 新潟市(新潟大学医学部)
  • Year and Date: 2011-12-10
• [Book] Oral Cancer ---Diagnosis and Therapy--- (2014)
  • Author(s): Tadaaki Kirita and Ken Omura ed
  • Total Pages: 300頁
  • Publisher: Springer Japan(発刊予定)