Human application of in vivo EPR Dosimetry

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kagawa University
• Principal Investigator: MIYAKE Minoru 香川大学, 医学部, 准教授 (20239370)
• Co-Investigator(Kenkyū-buntansha): MATSUI Yoshiro 香川大学, 医学部歯科口腔外科学講座, 教授 (10181687) ; IWASAKI Akinori 香川大学, 医学部附属病院, 助教 (10437676) ; YAMAGUCHI Ichiro 国立保健医療科学院, 上席主任研究官 (50311395) ; KUNUGIDA Naoki 国立保健医療科学院, 部長 (90178020)
• Co-Investigator(Renkei-kenkyūsha): HIRATA Hiroshi 北海道大学, 情報科学研究科, 教授 (60250958)
• Project Period (FY): 2011 – 2013
• Keywords: EPR / Dosimetry / 被ばく線量測定 / 歯エナメル質

Research Abstract

The measuring device for the radiation exposure dose in human teeth enamel using L-band in vivo Electron Paramagnetic Resonace (EPR) was newly developed. The loop-resonator designed for human upper central incisor were specially made, the S / N ratio with this new resonator, it was improved of 2.7 times that of the conventional apparatus. 95.0% sensitivity and 90.0% specificity in 1Gy irradiated specimen as the detection sensitivity were achieved. Further, the structure of the measuring setting was modified which can be measured in a sitting position, it can be reduced the measurement noise due to moving of the subjects. The measurement from 35 volunteers was performed, and the data of the background EPR signals in existing in enamel were obtained.

Research Products

• [Journal Article] Four-channel surface coil array for 300-MHz pulsed EPR imaging : proof of concept experimets (2014)
  • Author(s): A. Enomoto, H.Hirata, S.Matsumoto, K. Sato, S. Subramanian, M.C. Krishna
  • Journal Title: Magnetic Resonace in Medicine Volume: 71 Pages: 853-854
• [Journal Article] Four-channel surface coil array for sequential CW-EPR imaging acquisition (2013)
  • Author(s): A.Enomoto, M.Enomoto, H.Fujii, H.Hirata
  • Journal Title: J. Magnetic Resonance Volume: 234 Pages: 21-29
  • Peer Reviewed
• [Presentation] In vivo radiation dosimetry using L band EPR- The measurement from volunteers in FUKUSHIMA Prefecture, Japan (2013)
  • Author(s): M. Miyake, I.Yamaguchi , M.Umakoshi , H. Hirata, N.Kunugita, Y. Matsui, B. Williams, H. Swartz
  • Organizer: The 41^<st> Meeting of the International Society on Oxygen Transport to Tissue and the International EPR Conference
  • Place of Presentation: NH, USA
  • Year and Date: 20130622-28
• [Presentation] 生体EPRを用いた放射線被ばく線量測定-福島在住のボランティアからの計測 (2013)
  • Author(s): 三宅実、馬越通崇、山口一郎、岩崎昭憲、澤井史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎
  • Organizer: 第67回日本口腔科学会総会
  • Place of Presentation: 栃木県総合文化センター
  • Year and Date: 20130523-24
• [Presentation] The detection of radiation induced radicals from teeth enamel by in vivo EPR ( Electron paramagnetic Resonance) Dosimetry (2013)
  • Author(s): M. Miyake, I.Yamaguchi , M.Umakoshi , H. Hirata , N.Kunugita, Y. Matsui, A.Iwasaki
  • Organizer: J-RAPID Symposium
  • Place of Presentation: Katahira Sakura Hall, Tohoku University, Katahira Campus,2-1-1, Katahira, Aoba-ku, Sendai 980-8577, JAPAN
  • Year and Date: 20130306-07
• [Presentation] 生体EPR (Electron Paramagnetic Resonance :電子常磁性体共鳴法)を用いた前歯からの被ばく線量測定 (2012)
  • Author(s): 三宅実、馬越通崇、岩崎昭憲、今川尚子、澤井史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎、山口一郎
  • Organizer: 第66回日本口腔科学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 20120517-18
• [Presentation] EPR(Electron Paramagnetic Resonace :電子常磁性体共鳴法)を用いた生体被爆線量測定 (2011)
  • Author(s): 三宅実、山口一郎、岩崎昭憲、馬越通崇、今川尚子、澤井史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎
  • Organizer: 日本口腔科学会中国四国地方会
  • Place of Presentation: 松山市
  • Year and Date: 2011-11-21
• [Remarks] EPR線量測定研究結果
  • URL: http://trustrad.sixcore.jp/invivo_EPR/