Quantitative elucidation of change in fluorine associated with caries progression and inhibition

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: YAMAMOTO Hiroko 大阪大学, 歯学研究科(研究院), 招へい教員 (60448107)
• Co-Investigator(Kenkyū-buntansha): IWAMI Yukiteru 大阪大学, 大学院歯学研究科, 助教 (90303982)
• Co-Investigator(Renkei-kenkyūsha): YASUDA Keisuke 若狭湾エネルギー研究センター, 主任研究員 (00359241) ; OKUYAMA Katsushi 北海道大学, 大学院歯学研究科, 助教 (00322818)
• Project Period (FY): 2011 – 2013
• Keywords: フッ素 / 定量測定法 / う蝕 / 加速器 / PIXE/PIGE

Research Abstract

We have developed a new fluorine quantitative measurement method using a micro-PIXE (Proton Induced X-ray Emission) / PIGE (Proton Induced Gamma-ray Emission). By using this measurement method, it has become possible for the first time to catch the movement of fluorine upon demineralization of tooth. Further, it was shown that the fluorine in the tooth released with decalcified was again taken into the tooth.
The possibility that concentration value of fluorine in the tooth measured conventionally was contained both those not attached to the tooth, such as CaF2, and those attached to the tooth, has been shown.

Research Products

• [Journal Article] Validity of a portable microhardness testing system (Cariotester) for diagnosis of progression in active caries lesions (2013)
  • Author(s): Iwami Y, Yamamoto H, Hayashi M.
  • Journal Title: Dent Mater J Volume: 32(4) Pages: 667-672
  • Peer Reviewed
• [Journal Article] Comparison of Two Fluoride Regimens on Fluorine Uptake in Carious Enamel during pH-cycling (2012)
  • Author(s): H. Komatsu , Y. Matsuda , S. Ooki , N. Hasimoto , K. Okuyama , H. Yamamoto , Y. Iwami , S. Ebisu , M. Nomachi , K. Yasuda , T. Satoh and M. Kohka
  • Journal Title: JAEA Takasaki Annual Report 2011 JAEA-Review Volume: 2012-046 Pages: 82
  • Peer Reviewed
• [Journal Article] Measurement of fluorine distribution in carious enamel around 1.5-year aged fluoride-containing materials (2011)
  • Author(s): H. Komatsu, K. Kojima, Y. Funato, Y. Matsuda, T. Kijimura, K. Okuyama, H. Yamamoto, Y. Iwami, S. Ebisu, M. Nomachi, K. Yasuda, T. Satoh, M. Koka
  • Journal Title: JAEA Takasaki Annual Report 2010 JAEA-Review Volume: 2011-043 Pages: 85
  • Peer Reviewed
• [Journal Article] Progress of in-air microbeam system at the Wakasa Wan Energy Research Center (2011)
  • Author(s): K.Yasuda, M. Nomachi, Y. Sugaya, H. Yamamoto, H. Komatsu
  • Journal Title: Nuclear Instruments & Methods in Physics Research Section B Volume: 269 Pages: 2180-2183
  • Peer Reviewed
• [Journal Article] Fluoride uptake into human teeth from a fluoride-releasing a thin layer after a long period of filling (2011)
  • Author(s): Yamamoto H, Iwami Y, Ebisu S, Komatsu H, Nomachi M, Sugaya Y, Yasuda K.
  • Journal Title: IJPIXE Volume: (21) Pages: 31-38
  • Peer Reviewed
• [Journal Article] Fluorine analysis of human enamel around fluoride-containing materials under different pH-cycling by l-PIGE/PIXE system (2011)
  • Author(s): Komatsu H, Yamamoto H, Matsuda M, Kijimura T, Kinugawa M. Okuyama K, Nomachi M, Yasuda K, Satoh T, Oikawa S.
  • Journal Title: Nucl Instr and Meth Volume: B269 Pages: 2274-2277
  • Peer Reviewed
• [Journal Article] Fluorine analysis of human dentin surrounding resin composite after fluoride application by l-PIGE/PIXE analysis (2011)
  • Author(s): Okuyama K, Komatsu H, Yamamoto H, Pereira P.N.R, Bedran-Russo A.K, Nomachi M, Sato T, Sano H.
  • Journal Title: Nucl Instr and Meth Volume: B269 Pages: 2269-2273
  • Peer Reviewed
• [Journal Article] Relationship between laser fluorescence and bacterial invasion in arrested carious lesions (2011)
  • Author(s): Iwami Y, Yamamoto H, Hayashi M, Ebisu S.
  • Journal Title: Lasers Med Sci Volume: 26(4) Pages: 439-444
  • Peer Reviewed
• [Presentation] フッ素含有歯科材料からのフッ素と歯質との結合状態 (2013)
  • Author(s): 小松久憲、奥山克史、山本洋子、安田啓介、能町正治, 菅谷頼仁
  • Organizer: 第29回PIXEシンポジウム
  • Place of Presentation: 敦賀
  • Year and Date: 2013-11-15
• [Presentation] フッ化物含有歯面塗布剤適用後の歯根面におけるフッ素濃度分布 (2013)
  • Author(s): 奥山克史、小松久憲、大木彩子、橋本直樹、松田康裕、佐野英彦、山本洋子、林美加子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
  • Organizer: 第8回高崎量子応用研究シンポジウム-高崎量子応用研究所50周年を迎えて-
  • Place of Presentation: 高崎シティギャラリー
  • Year and Date: 2013-10-11
• [Presentation] Comparison of fluoride regimens on fluorine uptake in carious enamel (2013)
  • Author(s): Hashimoto N, Funato Y, Oki S, Matsuda Y, Okuyama K, Yamamoto H, Komatsu H, Sano H.
  • Organizer: 91h IADR総会
  • Place of Presentation: Seattle, USA
  • Year and Date: 2013-03-22
• [Presentation] Demineralize prevention of dentin with fluoride varnish via automatic pH-cycling (2013)
  • Author(s): Oki S, Matsuda Y, Hashimoto N, Okuyama K, Yamamoto H, Funato Y, Komatsu H, Sano H.
  • Organizer: 91h IADR総会
  • Place of Presentation: Seattle, USA
  • Year and Date: 2013-03-20
• [Presentation] フッ化物含有材料から歯質へのフッ化物取り込みの経時的変化 (2012)
  • Author(s): 奥山克史、小松久憲、山本洋子、安田啓介、船戸良基、木地村太基、佐野英彦
  • Organizer: 第137回日本歯科保存学会秋季学術大会
  • Place of Presentation: 広島
  • Year and Date: 2012-11-23
• [Presentation] 核反応による歯質内のフッ素分布測定(XI) (2012)
  • Author(s): 小松久憲、松田康裕、大木彩子、橋本直樹、奥山克史、山本洋子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
  • Organizer: 第7回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎
  • Year and Date: 2012-10-12
• [Presentation] Strontium Analysis of Carious Human Tooth around a Foluoride-containing Material using byμ-PIGE/PIXE System (2012)
  • Author(s): Komatsu H, Funato Y, Matsuda Y, Kijimura T, Okuyama K, Yamamoto H, Nomachi M, Yasuda K, Satoh T and Kohka M.
  • Organizer: 13th ICNMTA
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2012-07-24
• [Presentation] Fluoride concentration change in a tooth with acid treatment (2012)
  • Author(s): Yamamoto H, Iwami Y, Komatsu H,Nomachi M, Sugaya Y, and Yasuda K.
  • Organizer: 13th ICNMTA
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2012-07-23
• [Presentation] Fluorine-analysis of Cavity Walls in Glass-ionomer Restorations using PIGE/PIXE System (2012)
  • Author(s): H. Komatsu, K. Okuyama, T. Kijimura, H. Yamamato, Y. Iwami, K. Yasuda, M. Nomachi4 and Y. Sugaya
  • Organizer: 90h IADR総会
  • Place of Presentation: Iguaçu Falls, Brazil
  • Year and Date: 2012-06-21
• [Presentation] フッ素含有材料周囲齲蝕エナメル質におけるストロンチウム分布の測定 (2011)
  • Author(s): 船戸良基、小松久憲、小島健太郎、松田康裕、奥山克史、木地村太基、佐野英彦、山本洋子
  • Organizer: 第135回日本歯科保存学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-20
• [Presentation] 核反応による歯質内のフッ素分布測定(x) (2011)
  • Author(s): 小松久憲、小島健太郎、船戸良基、松田康裕、奥山克史、山本洋子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
  • Organizer: 第6回高崎量子応用研究シンポジウム
  • Place of Presentation: 高崎
  • Year and Date: 2011-10-13