2013 Fiscal Year Final Research Report
Elucidation of the mechanism of action in salivary protein histatin aimed at soft tissue injury treatment and regenerative medicine
| Project/Area Number |
23592906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YUKITA Akira 静岡大学, 教育学部, 講師 (80401214)
FUJINAMI Yoshiaki 松本歯科大学, 歯学部, 助手 (80392801)
TAKAHASHI Naoyuki 松本歯科大学, 総合歯科医学研究所, 教授 (90119222)
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| Co-Investigator(Renkei-kenkyūsha) |
WANG Pao-li 大阪歯科大学, 歯学部, 教授 (20213613)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 唾液蛋白質 / ヒスタチン |
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| Research Abstract |
Salivary protein histatins have antimicrobial properties and protect oral tissues from pathogens (e.g., periodontal pathogens and Candida albicans). However, very little is known about the function of histatins against host cells. In this study, we showed a part of mechanism enhancing cell proliferation by histatin in human gingival fibroblasts. It has also been suggested the possibility that histatin is concerned with other cell cycle regulatory functions. In addition, we showed the mechanism of anti-inflammatory action by histatin. These observations are advocated as new physiological function of salivary protein. These results are connected with regenerative medicine (and tissue engineering) and with development of anti-inflammatory agent.
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