Phosphodiesterase 5 inhibitor, using for erectile dysfunction treatment, may use the treatment of melanoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Mie University
• Principal Investigator: SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
• Co-Investigator(Kenkyū-buntansha): TAGAWA Toshiro 三重大学, 医学(系)研究科(研究院), 名誉教授 (30046346) ; MURATA Taku 三重大学, 医学部附属病院, 講師 (80242965)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 悪性黒色腫 / Phosphodiesterase

Outline of Final Research Achievements

We have already reported that the PDE1 signal affects the cell proliferation and motility in malignant melanoma cells. Therefore, we examined if the PDE5 inhibitor using for ED treatment, which also inhibits PDE1, is available as the therapeutic agent for malignant melanoma. Sildenafil inhibited cell motility of malignant melanoma MAA cells which expressed PDE1. Sildenafil was not effected for other oral malignant melanoma cells which did not express PDE1. As each oral malignant tumor cells showed the different PDE expression patterns and the effect of sildenafil varied by PDE expression pattern, PDE might be used for the personalized cancer therapy.

Free Research Field

口腔外科学