2013 Fiscal Year Final Research Report
development of therapeutic strategy and analysis of pathophysiology of pemphigus using autoantigen specific IgM monoclonal natibody
| Project/Area Number |
23592943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Taneaki 慶應義塾大学, 医学部, 教授 (00227745)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Shin 慶應義塾大学, 医学部, 助教 (80383719)
KODAKA Rie 慶應義塾大学, 医学部, 助教 (40383723)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 自己免疫疾患 / 天疱瘡 / 自己抗体 / モノクローナル抗体 / 病原性 |
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| Research Abstract |
e analyzed the anti-Dsg3 IgM antibody in pemphigus. In early stage of pemphigus patient serums, apparent anti-Dsg3IgM antibody was not detected. In PV model mice, anti-Dsg3 IgM antibody production in the early stage of the onset of PV was confirmed, however it was not significant than anti-Dsg3 IgG antibody production.Furthermore, we conducted examination for in vivo and in vitro analysis. The in vitro dissociation assay using normal human culture keratinocyte and the passive transfer assay using mouse were performed to confirm the preventive effect and therapeutic effect of the anti-Dsg3 IgM antibody. There are no apparent differences between subjects and controls for both effects. The detailed and continuous examination will be necessary in future. These results are useful for dissection of pathophysiology of PV and development of therapeutic strategy of PV.
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[Journal Article] Pathogenic Relevance of IgG and IgM Antibodies against Desmoglein 3 in Blister Formation in Pemphigus Vulgaris2011
Author(s)
Tsunoda K, Ota T, Saito M, Hata T, Shimizu A, Ishiko A, Yamada, T. Nakagawa, T. Kowalczyk, AP. Amagai, M
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Journal Title
Am J Pathol
Volume: 179(2)(S0002-9440)
Pages: 795-806
Peer Reviewed
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[Presentation] Erdheim−Chester病患者の歯科治療経験2014
Author(s)
石井秀太郎,山田由佳,黄地建仁,西須大徳,加藤伸,佐藤英和,藤田康平,池浦一裕,河奈裕正,角田和之,中川種昭
Organizer
第23回有病者歯科医療学会総会・学術大会
Place of Presentation
福岡
Year and Date
20140314-16
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[Presentation] 塩酸ピロカルピン内服に伴う多汗症状に対する白虎加人参湯の効果2013
Author(s)
池浦一裕,加藤伸,小高利絵,佐藤英和,藤田康平,西須大徳,角田博之,小澤夏生,永井哲夫,中川種昭,角田和之
Organizer
第23回日本口腔内科学会学術集会
Place of Presentation
東京
Year and Date
20130913-14
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[Presentation] 過去6年間の当科における自己臭症の臨床的検討2012
Author(s)
岩崎このみ,佐藤英和,池浦一裕,藤田康平,榎田洋平,山田有佳,加藤伸,小高利絵,畑澤知佳,角田和之,藤野雅美,永井哲夫,中川種昭
Organizer
第3回日本口臭学会総会
Place of Presentation
東京
Year and Date
20120707-08
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[Presentation] 線維素性唾液管炎の臨床的検討2011
Author(s)
池浦一裕,角田和之,加藤伸,小高利絵,小池晶彦,山田有佳,佐藤英和,藤田康平,永井哲夫,中川種昭
Organizer
第21回日本口腔粘膜学会総会
Place of Presentation
鹿児島
Year and Date
20110924-25
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