2013 Fiscal Year Final Research Report
Overexpression of the atypical protein kinase C rambda/iota in oral squamous cell carcinoma is associated with degrees of malignancy
| Project/Area Number |
23592972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
KOIZUMI Toshiyuki 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (80323575)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUDOH Kenji 横浜市立大学, 医学部, 准教授 (70303641)
KIOI Mitomu 横浜市立大学, 医学部, 准教授 (30545059)
NAGASHIMA Youji 横浜市立大学, 医学研究科, 准教授 (10217995)
AKIMOTO Kazunori 東京理科大学, 薬学部, 准教授 (70285104)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口腔扁平上皮癌 / aPKCλ/ι / Cancer stem cell / IL-6 |
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| Research Abstract |
Atypical protein kinase C lambda/iota (aPKC lambda/iota) is a cell polarity-regulating protein and is localized in the tight junction or apical membrane in the epithelial cell. Previous studies suggested that aPKC lambda/iota over-expression and abnormal localization were involved in tumor progression in some cancers. We investigated the correlation between the aPKC lambda/iota expression pattern and the clinicopathological parameters in oral squamous cell carcinoma (OSCC) cases immunohistochemically, and evaluated the utility of aPKC lambda/iota expression pattern as a biomarker for the degree of malignancy.
As a result, we found immunostaining for aPKC lambda/iota was more intense in poorly differentiated OSCC, compared with moderately- and well- differentiated cases. In addition, cases of younger ages showed intense immunostaining for aPKC lambda/iota than in older. These results suggest that aPKC lambda/iota overexpression might be useful to predict the clinical outcomes of OSCC.
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