2013 Fiscal Year Final Research Report
Intraepithelial 3D-architectural analysis of human tongue premalignant-cancerous progression
| Project/Area Number |
23592975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKABE Sadao 日本歯科大学, 生命歯学部, 客員教授 (70573731)
SHIMAZU Yoshihito 日本歯科大学, 生命歯学部, 講師 (10297947)
AOBA Takaaki 日本歯科大学, 生命歯学部, 教授 (30028807)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 歯学 / 病理学 / 舌癌 / 浸潤 / 組織立体構築 / 病理診断 |
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| Research Abstract |
The present study aimed to develop a clinical-pathological interactive diagnosis system, where we intend to correlate macroscopic mucosal changes with intraepithelial phenotypic alterations. To this goal, the degree of intraepithelial malignancy is classified into 4 grades, depending on CK13 down-expression and Ki-67 localization. The immunohistology-based 3D reconstruction helped to elucidate intraepithelial alterations taking place with premalignant to malignant transition and to assess quantitatively the number and size of cell clusters possessing discrete differentiation/proliferation phenotypes. The 3D analyses also delineated architectural abnormalities associated with the dysplasia-invasion transition. The present immunophenotypic evaluation disclosed complicated distribution of epithelial phenotypes and the degree of proliferative capacity in oral epithelial lesions.
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[Journal Article] Working Group 1 on the'Guidelines for Clinical and Pathological Studies of Oral Cancer'Scientific Committee, Japan Society for Oral Tumors : General rules for clinical and pathological studies on oral cancer : a synopsis2012
Author(s)
Izumo T, Kirita T, Ariji E, Ozeki S, Okada N, Okabe S, Okazaki Y, Omura K, Kusama M, Sato T, Shinohara M, Shimozato K, Shintani S, Tanaka Y, Nakayama E, Hayashi T, Miyazaki A, Yagishita H, Yamane M
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Journal Title
Jpn J Clin Oncol
Volume: 42
Pages: 1099-1109
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