2013 Fiscal Year Final Research Report
Basic research about bone regeneration and oral implant for craniofacial defect patients
| Project/Area Number |
23593054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Hiroo 松本歯科大学, 総合歯科医学研究所, 教授 (90147637)
NAKAMURA Midori 松本歯科大学, 歯学部, 准教授 (90278177)
YAGAMI Kimitoshi 松本歯科大学, 歯学部附属病院, 准教授 (00210211)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
NAKAMICHI Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨芽細胞 / 破骨細胞 / 遺伝子欠損マウス / 口蓋裂 / 骨再生 / Rykシグナル / Wntシグナル / 骨誘導因子 |
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| Research Abstract |
We generated systemic Ryk signal deficient mice. Ryk deficient mice exhibited a cleft palate and totally decrease of osteoclast number and osteoblast number in bone. Furthermore, we generated osteoclast-specific Ryk-deficient mice and osteoblast-specific Ryk-deficient mice. Interestingly, there are no cleft palate in both osteoclast-specific Ryk-deficient mice and osteoblast-specific Ryk-deficient mice. Osteoclast-specific Ryk-deficient mice have normal bone phenotype. These results suggest that Ryk expression in osteoclasts and osteoblasts is not essential for craniofacial defect.
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