2013 Fiscal Year Final Research Report
Interaction between S1P and DAMPs in periodontal inflammation
| Project/Area Number |
23593057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YANAGITA Manabu 大阪大学, 歯学研究科(研究院), 助教 (80379081)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Satoru 大阪大学, 歯学部附属病院, 講師 (40359849)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 歯周病 / リゾリン脂質 / ダメージ関連分子パターン |
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| Research Abstract |
In this study we have investigated the effects of S1P, bioactive lipid mediator, on inflammatory responses of gingival epithelial cells. S1P receptors, S1P2 and S1P3, are expressed in gingival epithelial cells. S1P increased to produce IL-8 from gingival epithelial cells in a dose-dependent manner. S1P-induced IL-8 production upregulated synergistically in the presence of HMGB-1 or Poly(I:C). S1P-induced IL-8 induction was suppressed in S1P2/S1P3 knockdown gingival epithelial cells. These findings suggest that S1P induce inflammation in gingival epithelial cells via S1P2/S1P3.
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[Journal Article] Adiponectin regulates functions of gingival fibroblasts and periodontal ligament cells2012
Author(s)
Iwayama T, Yanagita M, Mori K, Ozasa M, Sawada K, Kubota M, Miki K, Kojima Y, Takedachi M, Kitamura M, Shimabukuro Y, Hashikawa T and Murakami S
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Journal Title
Journal of Periodontal Research
Volume: 47
Pages: 563-571
Peer Reviewed
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