2013 Fiscal Year Final Research Report
Parameters of oral environment for perioperative patients of lung cancer based on two dimensional analysis of breath gasses
| Project/Area Number |
23593083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TANDA Naoko 東北大学, 大学病院, 助教 (00422121)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHIKAWA Yasushi 東北大学, 加齢医学研究所, 助教 (90333814)
TAKAHSI Nobuhiro 東北大学, 歯学研究科(研究院), 教授 (60183852)
KOSEKI Takeyoshi 東北大学, 歯学研究科(研究院), 教授 (80291128)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 周術期 / 肺癌 / 誤嚥性肺炎 / 呼気 / 口腔ケア / 口腔内細菌 / 口内気体 |
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| Research Abstract |
We analyzed gasses from exhaled and mouth air and saliva of perioperative patients of lung cancer at bedside before oral care, after oral care before operation, and after operation. Protective reflexes (cough and swallowing reflex) were also measured before and after operation. As for patients without postoperative pneumonia, oral care before operation increased ratio of salivary streptococci, usually known as healthy-associated bacteria, in anaerobic condition. Oral care also decreased total number of bacteria in saliva and decreased malodorous gasses. Acetone concentration increased after operation with rapid increase of CRP.
This study suggests possibility that non-invasive measuring volatile sulfide compounds and volatile organic compounds at bedside indicate oral environments and general inflammatory conditions of perioperative lung cancer.
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