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2013 Fiscal Year Final Research Report

The elucidation and development of a prevention method of the aspiration pneumonia development-of-symptoms mechanism in elderly people's hematopoietic stem cell transplantation

Research Project

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Project/Area Number 23593098
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionOhu University

Principal Investigator

KIYOURA Yusuke  奥羽大学, 歯学部, 教授 (90194951)

Co-Investigator(Renkei-kenkyūsha) TAMAI Riyoko  奥羽大学, 歯学部, 准教授 (90367566)
SUGAMATA Miho   (70530377)
Project Period (FY) 2011 – 2013
Keywords口腔カンジダ症 / Candida albicans / 誤嚥性肺炎 / 炎症性サイトカイン / 口腔ケア / 抗菌ペプチド
Research Abstract

Production of the mycotic stomatitis model using three kinds of different immunosuppressants (prednisolone, cyclosporin, methotrexate) was tried. As a result, in the mouse which performed immune suppression disposal by prednisolone on the day preceding a tongue application of Candida albicans, Remarkable weight loss was accepted three days after infection, and the pathological change formation (decomposition, an ulcer, and white moss) according to fixing of the bacillus of 10000 orders and human mycotic stomatitis was seen with the tongue. In the cyclosporin A and methotrexate, although two or more times inoculation and high-dose inoculation of a medicine were also tried, neither resulted in pathological change formation. That is, it was suggested that the cyclosporin A and methotrexate are difficult for model production of the mycotic stomatitis in a mouse.

  • Research Products

    (2 results)

All 2013 2012

All Presentation (2 results)

  • [Presentation] 口腔カンジダ症マウスモデルにおける免疫抑制剤の影響2013

    • Author(s)
      清浦有祐
    • Organizer
      日本老年歯科医学会第24回学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2013-06-06
  • [Presentation] 口腔カンジダ症マウスモデルを使用した新たな抗真菌薬感受性試験法の開発2012

    • Author(s)
      蜂谷眞也
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2012-11-10

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Published: 2015-07-16  

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