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2013 Fiscal Year Final Research Report

The interaction between audiovisual environment and brain: normal development and autism spectrum disorders

Research Project

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Project/Area Number 23601010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Children studies (Studies of environment on children)
Research InstitutionKyushu University

Principal Investigator

YAMASAKI TAKAO  九州大学, 医学(系)研究科(研究院), 特任助教 (70404069)

Co-Investigator(Renkei-kenkyūsha) KAMIO Yoko  国立精神神経医療研究センター, 部長 (00252445)
Project Period (FY) 2011 – 2013
Keywords自閉症スペクトラム / 視聴覚認知 / 事象関連電位 / 光トポグラフィー
Research Abstract

The hallmark feature of autism spectrum disorders (ASD) is impaired social interaction. It is possible that atypical sensory perception contributes to social cognition impairments in ASD. Thus, the present study was aimed to elucidate how the audiovisual abilities were functionally altered in individuals with ASD by using non-invasive neurophysiological methods such as visual evoked potentials (VEPs) and near-infrared spectroscopy (NIRS). In VEPs, we found that individuals with ASD have altered automatic visual processing for emotional faces within the lower level of the visual cortex. In NIRS, we demonstrated that a mother's voice modulated the activities of temporal voice and language areas in healthy children but not ASD children. Therefore, we conclude that these audiovisual impairments could be neural basis of the disrupted social cognition observed in individuals with ASD.

  • Research Products

    (51 results)

All 2014 2013 2012 2011 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (13 results) Book (5 results)

  • [Journal Article] Efficiency of a"small-world"brain network depends on consciousness level : a resting-state fMRI study2014

    • Author(s)
      Uehara T, Yamasaki T, et al.
    • Journal Title

      Cerebral Cortex

      Volume: 24(6) Pages: 1529-1539

    • DOI

      10.1093/cercor/bht004

    • Peer Reviewed
  • [Journal Article] ADバイオマーカー:電気生理学2014

    • Author(s)
      山﨑貴男,他
    • Journal Title

      認知神経科学

      Volume: 15(3) Pages: 193-198

    • Peer Reviewed
  • [Journal Article] 自閉症スペクトラムにおける視覚「ブロッブ障害仮説」の脳内基盤の検証:事象関連電位を用いた研究2014

    • Author(s)
      山﨑貴男,他
    • Journal Title

      発達研究

      Volume: 28 Pages: 181-188

    • Peer Reviewed
  • [Journal Article] 脳波モデルを用いた視覚誘発電位の振幅推定と特徴解析2014

    • Author(s)
      後藤和彦,杉剛直,松田吉隆,後藤聡,福田裕樹,後藤純信,山﨑貴男,他
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 113(409) Pages: 57-60

    • Peer Reviewed
  • [Journal Article] Rapid maturation of voice and linguistic processing systems in preschool children : a near-infrared spectroscopic study2013

    • Author(s)
      Yamasaki T, Ogata K, Maekawa T, Ijichi I, Katagiri M, Mitsudo T, Kamio Y, et al.
    • Journal Title

      Experimental Neurology

      Volume: 250 Pages: 313-320

    • DOI

      10.1016/j.expneurol.2013.10.005

    • Peer Reviewed
  • [Journal Article] Electrophysiological assessment of visual function in autism spectrum disorders2013

    • Author(s)
      Yamasaki T, Fujita T, Kamio Y, et al.
    • Journal Title

      Neuroscience and Biomedical Engineering

      Volume: 1(1) Pages: 5-12

    • DOI

      10.2174/2213385211301010003

    • Peer Reviewed
  • [Journal Article] Altered motion perception in mild cognitive impairment and Alzheimer's disease : An fMRI study2013

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      Clinical Neurophysiology

      Volume: 124(8) Pages: e37

    • DOI

      10.1016/j.clinph.2013.02.108

    • Peer Reviewed
  • [Journal Article] Altered automatic face processing in individuals with high-functioning autism spectrum disorders : evidence from visual evoked potentials2013

    • Author(s)
      Fujita T, Kamio Y, Yamasaki T, et al.
    • Journal Title

      Research in Autism Spectrum Disorders

      Volume: 7(6) Pages: 710-720

    • DOI

      10.1016/j.rasd.2013.03.001

    • Peer Reviewed
  • [Journal Article] Altered visual information processing systems in bipolar disorder : evidence from visual MMN and P32013

    • Author(s)
      Maekawa T, Katsuki S, Kishimoto J, Onitsuka T, Ogata K, Yamasaki T, et al.
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 7 Pages: 403

    • DOI

      10.3389/fnhum.2013.00403

    • Peer Reviewed
  • [Journal Article] Physiological state evaluation of VEP recording by combination of image and EEG2013

    • Author(s)
      Sueyoshi Y, Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T, et al.
    • Journal Title

      IEEE Engineering in Medicine and Biology Society 2013

      Pages: 3078

    • URL

      http://embc.embs.org/files/2013/3078_FI.pdf

    • Peer Reviewed
  • [Journal Article] Analysis of visual evoked potentials for different stimuli : effects of color combination and patterns2013

    • Author(s)
      Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T, et al.
    • Journal Title

      IEEE Engineering in Medicine and Biology Society 2013

      Pages: 3012

    • URL

      http://embc.embs.org/files/2013/3012_FI.pdf

    • Peer Reviewed
  • [Journal Article] Characteristic analysis of visual evoked potentials and posterior dominant rhythm by use of EEG model2013

    • Author(s)
      Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T, et al.
    • Journal Title

      International Conference on Control, Automation and Systems

      Pages: 233-236

    • DOI

      10.1109/ICCAS.2013.6703899

    • Peer Reviewed
  • [Journal Article] 等輝度色フリッカー刺激を用いた視覚誘発電位の定量解析-正弦波パターンと矩形波パターンによる反応性の相違-2013

    • Author(s)
      後藤和彦,杉剛直,松田吉隆,後藤聡,福田裕樹,後藤純信,山﨑貴男,他
    • Journal Title

      臨床神経生理学

      Volume: 41(1) Pages: 1-6

    • Peer Reviewed
  • [Journal Article] 視覚誘発電位頭皮上分布推定のための数式モデルを用いた成分分離2013

    • Author(s)
      後藤和彦,杉剛直,松田吉隆,後藤聡,福田裕樹,後藤純信,山﨑貴男,他
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 112(417) Pages: 1-6

    • Peer Reviewed
  • [Journal Article] Selective impairment of optic flow perception in amnestic mild cognitive impairment : evidence from event-related potentials2012

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      Selective impairment of optic flow perception in amnestic mild cognitive impairment : evidence from event-related potentials

      Volume: 3 Pages: 695-708

    • DOI

      10.3233/JAD-2011-110167

    • Peer Reviewed
  • [Journal Article] Understanding the pathophysiology of Alzheimer's disease and mild cognitive impairment : A mini review on fMRI and ERP studies2012

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      Neurology Research International 2012

      Pages: 719056

    • DOI

      10.1155/2012/719056

    • Peer Reviewed
  • [Journal Article] Relevance of in vivo neurophysiological biomarkers for mild cognitive impairment and Alzheimer's disease2012

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 31(S3) Pages: S137-154

    • DOI

      10.3233/JAD-2012-112093

    • Peer Reviewed
  • [Journal Article] A deficit of dorsal stream function in patients with mild cognitive impairment and Alzheimer's disease2012

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      2012 IEEE/ICME International Conference on Complex Medical Engineering

      Pages: 28-31

    • DOI

      10.1109/ICCME.2012.6275685

    • Peer Reviewed
  • [Journal Article] Differential roles of spatial frequency on reading processes for ideograms and phonograms : a high-density ERP study2012

    • Author(s)
      Horie S, Yamasaki T, et al.
    • Journal Title

      Neuroscience Research

      Volume: 72(1) Pages: 68-78

    • DOI

      10.1016/j.neures.2011.10.003.

    • Peer Reviewed
  • [Journal Article] Distinct role of spatial frequency in dissociative reading of ideograms and phonograms2012

    • Author(s)
      Horie S, Yamasaki T, et al.
    • Journal Title

      An fMRI study. Neuroimage

      Volume: 63(2) Pages: 979-988

    • DOI

      10.1016/j.neuroimage.2012.03.046.

    • Peer Reviewed
  • [Journal Article] Real-time evaluation system for accurate VEP recording and analysis2012

    • Author(s)
      Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T, et al.
    • Journal Title

      2012 IEEE/ICME International Conference on Complex Medical Engineering

      Pages: 429-434

    • DOI

      10.1109/ICCME.2012.6275686

    • Peer Reviewed
  • [Journal Article] 急性中毒症状が明らかでなく初期診断が困難であった間欠型一酸化炭素中毒の1例:急性発症性認知症の鑑別診断2012

    • Author(s)
      山﨑貴男,他
    • Journal Title

      認知神経科学

      Volume: 14(3) Pages: 193-198

    • Peer Reviewed
  • [Journal Article] アルツハイマー病の早期診断バイオマーカーを探る2012

    • Author(s)
      山﨑貴男,他
    • Journal Title

      福岡医学雑誌

      Volume: 103(11) Pages: 215-224

    • Peer Reviewed
  • [Journal Article] 視覚誘発電位記録状態の実時間評価システム2012

    • Author(s)
      後藤和彦,杉剛直,松田吉隆,後藤聡,福田裕樹,後藤純信,山﨑貴男,他
    • Journal Title

      生体医工学

      Volume: 50(5) Pages: 433-442

    • URL

      https://www.jstage.jst.go.jp/article/jsmbe/50/5/50_433/_pdf

    • Peer Reviewed
  • [Journal Article] 脳波モデルを用いた視覚誘発電位と後頭部優位律動の振幅推定2012

    • Author(s)
      後藤和彦,杉剛直,松田吉隆,後藤聡,福田裕樹,後藤純信,山﨑貴男,他
    • Journal Title

      生体医工学

      Volume: 50(6) Pages: 599-605

    • URL

      https://www.jstage.jst.go.jp/article/jsmbe/50/6/50_599/_pdf

    • Peer Reviewed
  • [Journal Article] Electrophysiological evidence for selective impairment of optic flow perception in autism spectrum disorder2011

    • Author(s)
      Yamasaki T, Fujita T, Ogata K, Goto Y, Munetsuna S, Kamio Y, et al.
    • Journal Title

      Research in Autism Spectrum Disorders

      Volume: 5(1) Pages: 400-407

    • DOI

      10.1016/j.rasd.2010.06.002

    • Peer Reviewed
  • [Journal Article] Parvocellular pathway impairment in autism spectrum disorder : evidence from visual evoked potentials2011

    • Author(s)
      Fujita T, Yamasaki T, Kamio Y,et al.
    • Journal Title

      Research in Autism Spectrum Disorders

      Volume: 5(1) Pages: 277-285

    • DOI

      10.1016/j.rasd.2010.04.009

    • Peer Reviewed
  • [Journal Article] Topography estimation of visual evoked potential by combinational use of mathematical models2011

    • Author(s)
      Goto K, Sugi T, Goto S, Goto Y, Yamasaki T, et al.
    • Journal Title

      2011 IEEE/ICME International Conference on Complex Medical Engineering

      Pages: 205-210

    • DOI

      10.1109/ICCME.2011.5876734

    • Peer Reviewed
  • [Journal Article] A deficit of dorsal stream function in patients with amnestic mild cognitive impairment2011

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      Clinical Neurophysiology

      Volume: 122(S1) Pages: S20

    • DOI

      10.1016/S1388-2457(11)60065-5

    • Peer Reviewed
  • [Journal Article] 正弦波パターンと矩形波パターンの2種類の刺激パターンによる視覚誘発電位の定量解析2011

    • Author(s)
      後藤和彦,杉剛直,後藤純信,山﨑貴男,他
    • Journal Title

      臨床神経生理学

      Volume: 39(1) Pages: 10-17

    • Peer Reviewed
  • [Journal Article] 視覚認知とその障害半側空間無視の病態生理2011

    • Author(s)
      後藤純信,吉田健,山﨑貴男,他
    • Journal Title

      認知神経科学

      Volume: 13(1) Pages: 71-78

    • Peer Reviewed
  • [Journal Article] Electrophysiological biomarkers for improved etiological diagnosis of cognitive impairment

    • Author(s)
      Yamasaki T,et al.
    • Journal Title

      Current Biomarker Findings

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Higher level but not lower level parallel visual pathways are functionally altered in patients with mild cognitive impairment

    • Author(s)
      Yamasaki T, et al.
    • Journal Title

      Clinical Neurophy siology

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Higher level but not lower level parallel visual pathways are functionally altered in patients with mild cognitive impairment2014

    • Author(s)
      Yamasaki T,et al.
    • Organizer
      30^<th> International Congress of Clinical Neurophysiology (ICCN) of the IFCN
    • Place of Presentation
      Berlin, (Poster)
    • Year and Date
      20140300
  • [Presentation] Characteristic analysis of visual evoked potentials and posterior dominant rhythm by use of EEG model2013

    • Author(s)
      Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T,et al.
    • Organizer
      2013 13th International Conference on Control, Automation and Systems
    • Place of Presentation
      Gwangju, Korea (Oral)
    • Year and Date
      20131000
  • [Presentation] Physiological state evaluation of VEP recording by combination of image and EEG2013

    • Author(s)
      Sueyoshi Y, Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T, et al.
    • Organizer
      The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka, Japan (Poster)
    • Year and Date
      20130700
  • [Presentation] Analysis of visual evoked potentials for different stimuli : effects of color combination and patterns2013

    • Author(s)
      Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T,et al.
    • Organizer
      The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka, Japan (Poster)
    • Year and Date
      20130700
  • [Presentation] ADバイオマーカー:電気生理学2013

    • Author(s)
      山﨑貴男,他
    • Organizer
      第18回認知神経科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20130700
  • [Presentation] Neural substrates of the temporal perception during successive visual stimuli : a high-density ERP study2012

    • Author(s)
      Nagaike A, Mitsudo T, Nakajima Y, Ogata K, Yamasaki T, et al.
    • Organizer
      The 16th Annual Meeting of the Association for the Scientific Study of Consciousness
    • Place of Presentation
      Brighton, UK (Poster)
    • Year and Date
      20120700
  • [Presentation] A deficit of dorsal stream function in patients with mild cognitive impairment and Alzheimer's disease2012

    • Author(s)
      Yamasaki T,et al.
    • Organizer
      2012 IEEE/ICME International Conference on Complex Medical Engineering
    • Place of Presentation
      Kobe, Japan (Symposium)
    • Year and Date
      20120700
  • [Presentation] Real-time evaluation system for accurate VEP recording and analysis2012

    • Author(s)
      Goto K, Sugi T, Matsuda Y, Goto S, Fukuda H, Goto Y, Yamasaki T, et al.
    • Organizer
      2012 IEEE/ICME International Conference on Complex Medical Engineering
    • Place of Presentation
      Kobe, Japan (Symposium)
    • Year and Date
      20120700
  • [Presentation] Electrophysiological evaluation of visual impairment in ASD2011

    • Author(s)
      Yamasaki T, Fujita T, Kamio Y,et al.
    • Organizer
      Exploring Autism Research Collaboration Between Japan and United States Joint Academic Conference on Autism Spectrum Disorders
    • Place of Presentation
      Tokyo, Japan (Poster)
    • Year and Date
      20111200
  • [Presentation] VEPを用いた自閉症スペクトラムにおける視機能評価小細胞系の障害2011

    • Author(s)
      藤田貴子,山﨑貴男,神尾陽子,他
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡(サテライトシンポジウム)
    • Year and Date
      20111100
  • [Presentation] A deficit of dorsal stream function in patients with amnestic mild cognitive impairment2011

    • Author(s)
      Yamasaki T, et al.
    • Organizer
      14th European Congress on Clinical Neurophysiology and 4th International Conference on Transcranial Magnetic and Direct Current Stimulation
    • Place of Presentation
      Italy (Symposium)
    • Year and Date
      20110600
  • [Presentation] An ERP study on temporal assimilation between the two neighboring short time intervals in the visual modality2011

    • Author(s)
      Nagaike A, Mitsudo T, Nakajima Y, Ogata K, Yamasaki T,et al.
    • Organizer
      The 15th Annual Meeting of the Association for the Scientific Study of Consciousness
    • Place of Presentation
      Kyoto, Japan (Poster)
    • Year and Date
      20110600
  • [Presentation] Topography estimation of visual evoked potential by combinational use of mathematical models2011

    • Author(s)
      Goto K, Sugi T, Goto S, Goto Y, Yamasaki T,et al.
    • Organizer
      2011 IEEE/ICME International Conference on Complex Medical Engineering
    • Place of Presentation
      Harbin, Heilongjiang, China (Oral)
    • Year and Date
      20110500
  • [Book] Electrophysiology of visual and auditory perception in autism spectrum disorders. In : Patel VB, Martin CR, Preedy VR, Eds. The Comprehensive Guide to Autism2014

    • Author(s)
      Yamasaki T, Maekawa T, Takahashi H, Fujita T, Kamio Y, et al.
    • Total Pages
      791-808
    • Publisher
      Springer Science+Business Media
  • [Book] Topography estimation of visual evoked potentials using a combination of mathematical models. In : Wu J, Ed. Biomedical Engineering and Cognitive Neuroscience for Healthcare : Interdisciplinary Applications2013

    • Author(s)
      Sugi T, Goto K, Goto S, Goto Y, Yamasaki T, et al.
    • Total Pages
      129-141
    • Publisher
      IGI Global
  • [Book] Electrophysiological assessment of the human visual system. In : Harris JM, Scott J, Eds. Neuroscience Research Progress, Visual cortex : Anatomy, functions and injuries2012

    • Author(s)
      Yamasaki T, et al.
    • Total Pages
      37-67
    • Publisher
      Nova Science Publishers
  • [Book] Motion perception in healthy humans and cognitive disorders. In : Wu J, Ed. Early detection and rehabilitation technologies for dementia : Neuroscience and biomedical applications. Hershey, Pennsylvania2011

    • Author(s)
      Yamasaki T, et al.
    • Total Pages
      156-161
    • Publisher
      IGI Global
  • [Book] Motion perception in autism spectrum disorder. In : Columbus AM, Ed. Advances in Psychology Research, Volume 82, New York2011

    • Author(s)
      Yamasaki T, Fujita T, Kamio Y, Tobimatsu S.
    • Total Pages
      197-211
    • Publisher
      Nova Science Publishers

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Published: 2015-07-16  

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