2013 Fiscal Year Final Research Report
The influence on bone marrow cells of the indoor environment chemicals: Analysis of dendritic cell differentiation and the Treg induction
| Project/Area Number |
23601027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Yasuhiro 産業医科大学, 医学部, 准教授 (10309958)
KURODA Etsushi 産業医科大学, 医学部, 講師 (10299604)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 室内環境化学物質 / 制御性T細部 / 骨髄由来細胞 / STAT5 |
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| Research Abstract |
As it has been reported that exposure of a wide variety of chemical substances to the child was increased, we investigated the effect of a substance chemical, such as formaldehyde and toluene, which is suspected in particular the effect of chemical prenatal period. From consideration of the exposure model mice, thymocytes immediately prepared from exposed mice after birth. Additionally, bone marrow derived cells were also highly activated.
Thus, the low concentration chemical prenatal exposure affected cellular events on the molecular level.
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