Development of low-radiation-dose retraction-contrast x-ray computed tomography for breast cancer diagnosis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23602002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: Yamagata University
• Principal Investigator: YUASA Tetsuya 山形大学, 理工学研究科, 教授 (30240146)
• Co-Investigator(Renkei-kenkyūsha): ANDO Masami 東京理科大学, 総合研究機構, 教授 (30013501) ; ICHIHARA Shu 名古屋医療センター, 臨床研究センター, 室長 (30426499) ; HUO Qinghai ㈱東芝メディカル
• Project Period (FY): 2011 – 2013
• Keywords: 屈折 / CT再構成 / 乳がん / 放射光X線 / 早期診断

Research Abstract

We proposed a novel x-ray CT imaging method based on phase contrast, which employs a Laue-case analyzer composed of Si single-crystal thin plate and two CCD cameras positioned downstream of the analyzer. In addition, we devised a data processing algorithm to extract refraction angle deviation from the incident beam direction, and a 3 dimensional CT reconstruction algorithm to reconstruct the refraction index distribution in a sample from the projections of refraction angle deviation. We demonstrated the effectiveness from the viewpoints of theory, simulation, and experiment. We clearly delineated TDLU (Terminal Duct Lobular Unit) in a pathological sample at a resolution of 10 microns.

Research Products

• [Journal Article] Crystal analyzer-based X-ray phase contrast imaging in the dark field: implementation and evaluation using excised tissue specimens (2013)
  • Author(s): M. Ando, N. Sunaguchi, Y. Wu, S. Do, Y. Sung, A. Louissaint, T. Yuasa, S. Ichihara, R. Gupta.
  • Journal Title: European Radiology Volume: 10 Pages: 1007/s00330-013-3021-9
  • Peer Reviewed
• [Journal Article] Fluorescent x-ray computed tomography using the pinhole effect for biomedical applications (2013)
  • Author(s): N. Sunaguchi, T. Yuasa, K. Hyodo, T. Zeniya.
  • Journal Title: Optics Communications Volume: Vol. 297, No. 15 Pages: 210-215
  • Peer Reviewed
• [Journal Article] A physico-mathematical formulation based on ray equation for reconstructing refraction-based 3-D image of soft tissue (2013)
  • Author(s): T. Yuasa, N. Sunaguchi, S. Ichihara, M. Ando.
  • Journal Title: Journal of Instrumentation Volume: Vol. 8, Iss. 5 Pages: C05001
  • Peer Reviewed
• [Journal Article] Synchrotron-based non-destructive diffraction-enhanced imaging systems to image walnut at 20 keV (2013)
  • Author(s): D. V. Rao, M. Bhaskaraiah, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa, Z. Zhong, T. Takeda, G. E. Gigante.
  • Journal Title: Journal of Food Measurement and Characterization Volume: Vol. 7, No. 1 Pages: 13-21
  • Peer Reviewed
• [Journal Article] The feasibility study on 3-dimensional fluorescent x-ray computed tomography using the pinhole effect for biomedical applications (2013)
  • Author(s): N. Sunaguchi, T. Yuasa, K. Hyodo, T. Zeniya.
  • Journal Title: Proc. IEEE EMBC 2013 Pages: 2348-2351
  • Peer Reviewed
• [Journal Article] Refractive-index based tomosynthesis using dark-field imaging optics (2013)
  • Author(s): N. Sunaguchi, T. Yuasa, S. Ichihara, Q. Huo, M. Sakai, Y. Wu, D. Shimao, M. Ando.
  • Journal Title: Journal of Physics: Conference Series Volume: Vol. 425, Iss. 19 Pages: 192012
  • Peer Reviewed
• [Journal Article] Development of highly sensitivity X-ray multiple-times-diffraction enhanced imaging (M-DEI) (2013)
  • Author(s): Y. Wu, K. Hyodo, N. Sunaguchi, T. Yuasa, M. Ando.
  • Journal Title: Journal of Physics: Conference Series Volume: Vol. 425, Iss. 19 Pages: 192008
  • Peer Reviewed
• [Journal Article] Tissue visualization using x-ray dark-field imaging towards pathological goal (2013)
  • Author(s): M. Ando, Y. Chikaura, T. Endo, R. Gupta, Q. Huo, K. Hyodo, S. Ichihara, K. Mori, Y. Nakao, N. Ohura, N. Sunaguchi, Y. Suzuki, Y. Wu, T. Yuasa, Z. Xiaowei.
  • Journal Title: Journal of Physics: Conference Series Volume: Vol. 425, Iss. 19 Pages: 192006
  • Peer Reviewed
• [Journal Article] Visualization of microvascular proliferation as a tumor infiltration structure in rat glioma specimens using the diffraction-enhanced imaging in-plane CT technique (2012)
  • Author(s): S.-J. Seo, N. Sunaguchi, T. Yuasa, Q. Huo, M. Ando, G.-H. Choi, H.-T. Kim, K.-H. Kim, E.-J. Jeong, W.-S. Chang and J.-K. Kim.
  • Journal Title: Physics in Medicine and Biology Volume: Vol. 57, No. 5 Pages: 1251-1262
  • Peer Reviewed
• [Journal Article] Synchrotron-based DEI for bio-imaging and DEI-CT to image phantoms with contrast agents (2012)
  • Author(s): D.V. Rao, M. Swapna, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa, Z. Zhong, T. Takeda, and G.E. Gigante.
  • Journal Title: Applied Radiation and Isotopes Volume: Vol. 70, No. 8 Pages: 1570-1578
  • Peer Reviewed
• [Journal Article] Embedded soft-tissue image mechanism of a small anima shell with synchrotron-based micro-CT (2012)
  • Author(s): D.V. Rao, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa, T. Takeda, G.E. Gigante.
  • Journal Title: Journal of X-Ray Science and Technology Volume: Vol. 20, No. 3 Pages: 291-299
  • Peer Reviewed
• [Journal Article] Synchrotron-based x-ray fluorescence applied to invertebrates to investigate the role of essential trace elements in a biological process, 2.5-D and 3-D breast tissue visualization under x-ray dark field imaging (2012)
  • Author(s): D.V. Rao, M. Swapna, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa, T. Takeda, G.E. Gigante.
  • Journal Title: PHYSICA SCRIPTA Volume: Vol. 85, No. 3 Pages: 035805
  • Peer Reviewed
• [Journal Article] Very high contrast and very high spatial resolution 2-D (2012)
  • Author(s): M. Ando, Q. Huo, S. Ichihara, T. Endo, T. Yuasa, N. Sunaguchi, K. Mori.
  • Journal Title: Breast Imaging (Springer Berlin Heidelberg) Pages: 104-110
  • Peer Reviewed
• [Journal Article] Refraction-contrast tomosynthesis imaging using dark-field imaging optics (2011)
  • Author(s): N. Sunaguchi, T. Yuasa, Q. Huo, S. Ichihara, and M. Ando.
  • Journal Title: Applied Physics Letters Volume: No. 99 Pages: 103704
  • Peer Reviewed
• [Journal Article] Convolution reconstruction algorithm for refraction-contrast computed tomography using a Laue-case analyzer for dark field imaging (2011)
  • Author(s): N. Sunaguchi, T. Yuasa, Q. Huo, and M. Ando.
  • Journal Title: Optics Letters Volume: Vol. 36, No. 3 Pages: 391-393
  • Peer Reviewed
• [Journal Article] 生体組織のためのDark Field Imaging法に基づく屈折コントラストX線CT (2011)
  • Author(s): 砂口尚輝,湯浅哲也,霍慶凱,市原周,安藤正海
  • Journal Title: 計測自動制御学会論文集 Volume: Vol. 47, No. 10 Pages: 459-467
  • Peer Reviewed
• [Journal Article] Synchrotron-based small-angle x-ray scattering from biogenic materials (2011)
  • Author(s): D.V. Rao, M. Swapna, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa, T. Takeda, G.E. Gigante.
  • Journal Title: PHYSICA SCRIPTA Volume: Vol. 84, No. 6 Pages: 065802
  • Peer Reviewed
• [Journal Article] Synchrotron-based x-ray fluorescence, imaging and elemental mapping from biological samples (2011)
  • Author(s): D.V. Rao, M. Swapna, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa, T. Takeda, G.E. Gigante.
  • Journal Title: PRAMANA-Journal of Physics Volume: Vol. 76, No. 2 Pages: 261-2697
  • Peer Reviewed
• [Presentation] A physico-mathematical formula for easily reconstructing refraction-based image of soft tissue (2012)
  • Author(s): T. Yuasa.
  • Organizer: 7^<th> International Symposium on Medical Application of Synchrotron Radiation
  • Place of Presentation: Shanghai
  • Year and Date: 20121017-20
  • Invited
• [Presentation] Reconstruction Theory of Refraction Contrast Computed Tomography (2011)
  • Author(s): T. Yuasa.
  • Organizer: 4^<th> Asian Meeting on Synchrotron Radiation Biomedical Imaging
  • Place of Presentation: Xining
  • Year and Date: 20110821-22
  • Invited
• [Presentation] Reconstruction Algorithm of Refraction-Based Computed Tomography from Viewpoint of X-Ray Optics (2011)
  • Author(s): T. Yuasa.
  • Organizer: International Forum on Medical Imaging in Asia 2011
  • Place of Presentation: Naha
  • Year and Date: 20110118-19
  • Invited