2013 Fiscal Year Final Research Report
Abnormal energy and genes in diabetic cardiomyopathy and nephropathy
| Project/Area Number |
23602012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics/Radiological Technology
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 標識脂肪酸 / 医療薬剤学 |
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| Research Abstract |
A majority of hospitalizations for complications of diabetes are linked to nephrotic diseases (Diabetic Nephropathy) and cardiovascular diseases (Diabetic Cardiomyopathy, Myocardial Infarction etc.). We determined cardiac function, left ventricular remodeling, and cardiac sympathetic nerve function with iodine-125labeled metaiodobenzylguanidine. Long-chain fatty acids are major cardiac energy substrates, and decreased myocardial fatty acid metabolism using I-labeled 9- pentadecanoic acid has been demonstrated in diabetic cardiomyopathy and failing heart. Long-term drug treatment not only prevented left ventricular remodeling and improved cardiac function in rat with diabetic and dilated cardiomyopathy, but also restored cardiac sympathetic tone to hold norepinephrine in the heart. It is important that protective food function as underpinning strategy for disease prevention.
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