2014 Fiscal Year Final Research Report
Search for the PET probes and comparison between them towards non-invasive beta cell mass measurement in human
| Project/Area Number |
23602016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics/Radiological Technology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAKO Takeo 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別研究員 (30525556)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Koki 熊本大学, 医学部, 助教 (50525798)
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| Research Collaborator |
KATAOKA Yousuke
CUI Yilong
TOYODA Hiroshi
NISHIMURA Mie
HAYASHINAKA Emi
WADA Yasuhiro
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 分子イメージング / PET / 膵β細胞 / 糖尿病 |
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| Outline of Final Research Achievements |
Pancreatic beta cell mass is thought to be useful biomarker for diabetes, but so far the only way to measure beta cell mass is the biopsy, which is so invasive that it cannot be done before diagnosis nor so many times even after diagnosis. Therefore, non-invasive method to quantify the beta cell mass is needed.
Positron Emission Tomograpy (PET) has good sensitivity and quantificapability, compared with other imaging modalities. Our goal is to establish non-invasive measurement of beta cell mass with PET. We performed PET studies with radiolabeled somatostatin analogs and revealed that they were good candidates for evaluation of beta cell mass.
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| Free Research Field |
核医学
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