Fundamental and clinical studies on angiogenesis by vibration therapy: Why does the comfortable vibration promote wound healing?

2013 Fiscal Year Final Research Report

• Project/Area Number: 23612001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Mechanobiology
• Research Institution: The University of Tokyo
• Principal Investigator: NAGASE Takashi 東京大学, 医学(系)研究科(研究院), 客員研究員 (00359613)
• Co-Investigator(Kenkyū-buntansha): NAKAGAMI Gojiro 東京大学, 大学院医学系研究科, 講師 (70547827) ; MINEMATSU Takeo 東京大学, 大学院医学系研究科, 講師 (00398752) ; MORI Taketoshi 東京大学, 大学院医学系研究科, 准教授 (20272586) ; AKASE Tomoko 横浜市立大学, 医学部, 教授 (50276630)
• Co-Investigator(Renkei-kenkyūsha): SANADA Hiromi 東京大学, 大学院医学系研究科, 教授 (50143920)
• Project Period (FY): 2011 – 2013
• Keywords: 創傷看護学

Research Abstract

Our research group have developed a novel wound healing vibrator. In this study, we investigated the effects and its molecular mechanisms of vibrator on the deep tissue injuries (DTIs) and diabetic foot ulcers, for which the effective intervention have not been established.
We investigated the effects of vibration on DTI in the animal study, in which we used a unique model rat for DTI deterioration. We revealed that vibration improved the tissue hypoxia and remarkably attenuated the ulceration of wounds.
We conducted a randomized control study in two hospitals in Indonesia (international collaborative research) to reveal the promoting effect of vibration on diabetic foot ulcer. We found the significant decreases of wound area reduction and healing period in the vibration group.

Research Products

• [Journal Article] Establishment of a Novel Rat Model for Deep Tissue Injury Deterioration (2013)
  • Author(s): Sari Y, Minematsu T, Huang L, Noguchi H, Mori T, Nakagami G, Nagase T, Oe M, Sugama J, Yoshimura K, Sanada H
  • Journal Title: International Wound Journal
  • DOI: 10.1111/iwj.12082.[Epubaheadofprint]
  • Peer Reviewed
• [Presentation] New insight in etiology of deep tissue injury (2012)
  • Author(s): Nagase T, Sanada H, Nakagami G, Minematsu T, Sari Y, Sugama J
  • Organizer: 4th Congress of the World Union of Wound Healing Societies
  • Place of Presentation: Yokohama (Japan)
  • Year and Date: 20120902-06
• [Presentation] Vibration attenuates the deterioration of deep tissue injury (2012)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 4th Congress of the World Union of Wound Healing Societies
  • Place of Presentation: Yokohama (Japan)
  • Year and Date: 20120902-06
• [Presentation] Activation of MMP-2 and MMP-9 during Deterioration of Deep Tissue Injury in Rats (2011)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 第13回日本褥瘡学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20110826-27
• [Presentation] Vibration attenuates the deterioration of deep tissue injury (2011)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 第13回日本褥瘡学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20110826-27
• [Presentation] Establishment of novel model for deterioration of deep tissue injury in rat (2011)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 第20回日本創傷・オストミー・失禁管理学会学術集会
  • Place of Presentation: 石川
  • Year and Date: 20110521-22
• [Book] Chapter 3, Nursing Biology. In, Bioengineering Nursing : New horizons of nursing research (Sanada H, Mori T & Nagase T, Eds) (2014)
  • Author(s): Minematsu T, Tamai N, Nishijima Y
  • Total Pages: 25-59
  • Publisher: Nova Science Publisher