2013 Fiscal Year Final Research Report
Epigenetic regulation of primary lymphoid organ microenvironment
| Project/Area Number |
23616003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
epigenetics
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| Research Institution | Hiroshima University |
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Principal Investigator |
KANNO Masamoto 広島大学, 医歯薬保健学研究院(医), 教授 (40161393)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ポリコーム / タンパク質複合体 / KOマウス / lincRNA / 胸腺 / T細胞分化 |
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| Research Abstract |
We succeeded to purify thymic development stage specific PRC1 protein complexes. At ETP stage, PRC1.2 is major form of PRC1, however, at DN3 PRC1.4 form of PRC1 is major form. This corresponds well for the phenotype of different PCGF gene KO mice. We also succeeded to establish several floxed PcG gene KO mice. Also we identified new lincRNA with might bind with PRC2
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[Journal Article] Arf/p53 module, which induces apoptosis, downregulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs2013
Author(s)
Atsumi Y., Inase A., Osawa T., Sugihara E., Sakasai R., Fujimori H., Teraoka H., Saya H., Kanno M., Tashiro F., Nakagama H., Matsuntani M., Yoshioka K.
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Journal Title
J. Biol. Chem
Volume: 288(19)
Pages: 13269-13277
DOI
Peer Reviewed
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[Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2012
Author(s)
Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H,Kanno M , Miwa M, Okada S, Andreeff M, Saya H
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Journal Title
Oncogene
Volume: 7;31(23)
Pages: 2849-2861
DOI
Peer Reviewed
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