2013 Fiscal Year Final Research Report
Control of stem cell migration by small chemical compounds and their application to regenerative medicine
| Project/Area Number |
23618007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA AKITO 大阪大学, 産学連携本部, 特任教授 (50298882)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUMOTO Tadashi 大阪大学, 産学連携本部, 特任助教授 (70594117)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医学 / ｼｸﾞﾅﾙ伝達 / 細胞・組織 |
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| Research Abstract |
Previous studies have identified several small chemical compounds that activate the migration of mesenchymal stem cells. In present study, we analyzed the characteristics of stem cell migration by stimulation of the compounds. Furthermore, we examined the effect of migration activity and tissue regeneration of stem cells by compound stimulation in animal tissues. As a result, PL-C1 and PL-17 could enhance tissue regeneration in the skin wound model using diabetic mice, and could enhance the accumulation of stem cells with a compound applied in stem cell attraction model by skin wound. It is expected to be applied to a variety of tissue regeneration model using these compounds.
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Research Products
(12 results)
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[Journal Article] Mallotus philippinensis derver components enhance the mobilization of mesenchymal stem cells for skin regeneration2014
Author(s)
Furumoto T, Ozawa N, Inami Y, Toyoshima M, Fujita K, Zaiki K, Sahara S, Akita M, Kitamura K, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A
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Journal Title
Phytomedicine
Volume: 21(3)
Pages: 247-253
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[Journal Article] HIG1, a novel regulator of mitochondrial y-secretase, maintains normal mitochondrial function2012
Author(s)
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
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Journal Title
The FASE Journal
Volume: 26 (6)
Pages: 2306-2317
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[Journal Article] Modification of a novel angiogenic peptide, AG30,for the development of novel therapeutic gents2012
Author(s)
Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R,Tamai K, Tomono K, Kaneda Y
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Journal Title
Journal of Cellular and Molecular Medicine
Volume: 16 (7)
Pages: 1629-1639
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[Presentation] Mallotus philippinensis derived components enhance the mobilization of mesenchymal stem cells for skin regeneration2013
Author(s)
Furumoto T, Fujita K, Toyoshima M, Zaiki K, Sahara S, Akita M, Ozawa N, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A
Organizer
第36回日本分子生物学会年会
Place of Presentation
神戸国際展示場
Year and Date
2013-12-05
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