Analysis of the molecular mechanisms to ensure the robustness of neuronal polarity

2012 Fiscal Year Final Research Report

• Project/Area Number: 23650168
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neuroscience in general
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: INAGAKI Naoyuki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 (20223216)
• Project Period (FY): 2011 – 2012
• Keywords: 脳・神経 / 発生・分化 / 神経科学 / 軸索輸送 / 細胞骨格 / バレル構造

Research Abstract

In this study, we analysed the functions of Rab33a which directlyinteract with Singar1; singar1 is involved in the robustness of neuronal polarity. Our datasuggest that Rab33a mediates the anterograde axonal transport of post-Golgisynaptophysin-positive vesicles, thereby contributing to membrane insertion at the growthcones and to axon outgrowth. The functional relationship between Singar1 and Rab33a isan important issue for future studies.

Research Products

• [Journal Article] Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth (2012)
  • Author(s): Nakazawa, H., Sada, T., Toriyama, M., Tago, K., Sugiura, T., Fukuda, M. and Inagaki, N.
  • Journal Title: J. Neurosci Volume: 32 Pages: 12712-12725
• [Presentation] Rab33a stimulates vesicular trafficking and promotes axon outgrowth (2012)
  • Author(s): Nakazawa, H., Sada, T., Toriyama, M., Tago, K., Sugiura, T., Fukuda, M., and Inagaki, N.
  • Organizer: 第45回日本発生生物学会・第64回日本細胞生物学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-05-28
• [Presentation] Rab33a stimulates vesicular trafficking and promotes axon outgrowth (2011)
  • Author(s): Nakazawa, H., Sada, T., Toriyama, M., Tago, K., Fukuda, M., and Inagaki, N.
  • Organizer: 2011 Annual Meeting of the American Society for Cell Biology
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-12-06
• [Presentation] Rab33a stimulates vesicular trafficking and promotes axon outgrowth (2011)
  • Author(s): Nakazawa, H., Sada, T., Toriyama, M., Tago, K., Fukuda, M., and Inagaki, N.
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-27
• [Book] 脳の発生学 (2013)
  • Author(s): 宮田卓樹,山本亘彦
  • Publisher: 化学同人
• [Remarks]
  • URL: http://nippon.naist.jp/inagaki_g/
• [Patent(Industrial Property Rights)] Singar の発現または機能の抑制による神経軸索の形成・伸長と神経再生への応用 (2012)
  • Inventor(s): 稲垣直之, 森達也, 小原収, 長瀬隆弘
  • Industrial Property Rights Holder: 奈良先端科学技術際学院大学, かずさDNA 研究所
  • Industrial Property Number: 特許第4952944 号
  • Acquisition Date: 2012-03-23