2012 Fiscal Year Final Research Report
Identification and analysis of post-translational protein modifications of neurotransmitter receptors
| Project/Area Number |
23650187
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HAYASHI Takashi 東京大学, 大学院・医学系研究科, 助教 (80547472)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経伝達物質 / グルタミン酸 / 受容体 / 翻訳後修飾 |
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| Research Abstract |
In the ionotropic glutamate receptors (iGluRs), post-translational protein modifications of AMPA receptors and NMDA receptors modulate these receptor ion channel properties as well as the membrane trafficking of receptors to/from the post-synapses. Through this program, we focused on palmitoylation-dependent regulation of iGluR function. Our findings revealed novel roles of palmitoylation of AMPA receptor-binding protein GRIP1, which regulates dynamic trafficking of AMPA receptors in cortical and hippocampal neurons. In addition, we showed that synaptic delivery of NMDA receptors is controlled by their dual palmitoylation in hippocampal CA1 pyramidal neurons.
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