2013 Fiscal Year Final Research Report
Reconstruction of gait capability of cerebellar ataxia using neuro-engineering procedures
| Project/Area Number |
23650202
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OTA Jun 東京大学, 人工物工学研究センター, 教授 (50233127)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 小脳性歩行失調 / 姿勢筋緊張 / 網様体脊髄路 / 機能再建 / 除脳動物 / 機能的電気刺激 / 脳深部刺激 / ブレインマシンインターフェイス |
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| Research Abstract |
This is a basic study aiming at reconstructing gait ataxia of cerebellar damaged animals using neuro-engineering procedures. For this purpose, here we elucidated locomotor ataxia of animals following damages of various areas of the cerebellum. Rats with damages of medial cerebellum displayed hypotonia with severe postural instability and locomotor ataxia. Although such locomotor deficits were not prominent in the rats with damages of lateral cerebellum, they became hypokinetsia when they encountered unfamiliar circumstances. By removal of the whole cerebellum, spontaneous movements were mostly disappeared and the rats became akinesia. These results suggest that the cerebellum plays crucial roles in initiation of locomotor behaviors, and the medial and the lateral part may contribute to posture-locomotor synergies and to locomotor adaptation, respectively. Different neuro-engineering procedures will be required to reconstructing gait ataxia with damages of medial and lateral cerebellum.
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[Presentation] 身体性システム科学の構築を目指して2013
Author(s)
太田順,今水寛,関和彦,淺間一,出江紳一,芳賀信彦,近藤敏行,内藤栄一,村田哲,花川隆,高草木薫,稲巴哲也
Organizer
継続自動制御学会システム・情報部門学術講演会
Place of Presentation
大津
Year and Date
20131118-20
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