2012 Fiscal Year Final Research Report
Comprehensive analysis of in vivo substrates of protein kinase C
| Project/Area Number |
23650214
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Fusional basic brain science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
AIBA Atsu 東京大学, 大学院・医学系研究科, 教授 (20271116)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 脳分子プロファイリング |
|---|
| Research Abstract |
Protein kinase C (PKC) γ is involved in cerebellar functions such as motor coordination and elimination of climbing fiber-Purkinje cell synapses. Molecular mechanisms of PKCγ-regulating cerebellar processes are elusive, due to the heretofore undescribed in vivo substrates of PKCγ. In this study, a series of candidate molecules for PKCγ substrates in mouse cerebellum was identifiedby quantitative phospho-proteomic analysis.
|
Research Products
(10 results)
-
[Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin2013
Author(s)
Asahara S, Shibutani Y, Teruyama K, InoueHY, Kawada Y, Etoh H, Matsuda T,Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y
-
Journal Title
DOI
Peer Reviewed
-
-
-
[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2012
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
-
Journal Title
Mechanisms of Development
Volume: 129
Pages: 38-50
DOI
Peer Reviewed
-
[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012
Author(s)
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T,Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R
-
Journal Title
Blood
Volume: 119
Pages: e45-56
DOI
Peer Reviewed
-
-
-
-
-
