Development of a model mouse line for hair graying

2014 Fiscal Year Final Research Report

• Project/Area Number: 23650241
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Nagoya University (2012-2014); Chubu University (2011)
• Principal Investigator: MASASHI Kato 名古屋大学, 医学(系)研究科(研究院), 教授 (10281073)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Kozue 中部大学, 生命健康科学部, 准教授 (80345884) ; GOTO Yuji 中部大学, 生命健康科学部, 助手 (70362522)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: モデル動物 / 遺伝子改変マウス / 白髪 / メラノサイト

Outline of Final Research Achievements

Hair graying is an ordinary disorder for hair pigmentation and a symbol for aging. At present, mechanism of hair graying remains largely unknown, whereas reports for genetically modified mice with changing levels of hair pigmentation are increasing in international scientific journals, according to the recent progression of molecular biology. However, there is very limited report showing model mouse lines for hair graying with aging. We developed original mouse lines for hair graying with aging. In this study, we clarify pathogenesis and molecular mechanism of hair graying in the mice. We also provide the evidence that the mice could be appropriate model mice for hair graying with aging. Moreover, we challenge to develop molecular target therapy for anti-hair graying.

Free Research Field

分子生物学、皮膚科学、衛生学