2013 Fiscal Year Final Research Report
Design of apoptotic cell membrane mimetic smart polymers for treatment of acute heart failure
| Project/Area Number |
23650295
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
EBARA Mitsuhiro 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10452393)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バイオマテリアル / 炎症細胞 / スマート材料 / 急性疾患 / アポトーシス |
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| Research Abstract |
We newly synthesized monomers with phosphatidylserine (PS) group to examine the potential ability of apoptotic cell-mimetic polymers as an alternative tool for anti-inflammatory therapy. We polymerized monomer, and evaluated physical properties and anti-inflammatory activity of the obtained polymer. Increased secretion of anti-inflammatory cytokines from macrophages was observed when exposed to PS-polymers.
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Research Products
(44 results)
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[Journal Article] Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure2014
Author(s)
D . Mosqueira, S . Pagliari, K . Uto, M . Ebara, S . Romanazzo, C . Escobedo-Lucea, J . Nakanishi, A . Taniguchi, O . Franzese, P . D . Nordo, M . J . Goumans, E . Traversa, P . a Pinto-do-Ó, T . Aoyagi, G . Forte
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Journal Title
ACS NANO
Volume: 8
Pages: 2033-2047
DOI
Peer Reviewed
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