Postural-related Cerebral Hemodynamic Responses Assessed by Near Infrared Spectroscopy in Patients with Chronic Cerebral Infarction

2014 Fiscal Year Final Research Report

• Project/Area Number: 23650320
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: IRISAWA Hiroshi 浜松医科大学, 医学部附属病院, 特任研究員 (70467231)
• Co-Investigator(Kenkyū-buntansha): WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803) ; TAKEUCHI Kazuhiko 浜松医科大学, 医学部, 准教授 (00419425) ; MIZUSHIMA Takashi 浜松医科大学, 医学部付属病院, 准教授 (80279348)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 脳血流 / 近赤外時間分解分光法 / 脳梗塞

Outline of Final Research Achievements

Near infrared spectroscopy (NIRS) is a non-invasive optical technique to monitor dynamic cerebral tissue blood volume. We hypothesized that chronic chronic cerebral infarction (CI) was independently associated with decreasing cerebral blood flow (CBF) during active orthostatic stress. We designed a cross sectional study to investigate the relation between chronic CI and the postural-related changes of CBF. A total of 100 subjects with or without chronic CI were enrolled in this study. Postural-related changes of average bilateral frontal cortical CBF were non-invasively and continuously measured by using NIRS during orthostatic stress. The proportion of decreasing CBF during active orthostatic stress was higher in patients with chronic CI than in those without chronic CI. The odds ratio (OR) for decreasing CBF during active orthostatic stress in patients with chronic CI was 3.22. Chronic CI was an independent risk factor for decreasing CBF during active orthostatic stress.

Free Research Field

医学