2013 Fiscal Year Final Research Report
Identification of regeneration promoting factors
| Project/Area Number |
23650433
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Osaka University |
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Principal Investigator |
FUKADA So-ichiro 大阪大学, 薬学研究科(研究院), 研究員 (20432445)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨格筋 / 加齢 / 幹細胞 |
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| Research Abstract |
Skeletal muscle has great regenerative potential that is dependent on muscle stem cells, also known as satellite cells. Intriguingly, the regenerative potential is dependent on mouse strain. We found that C57BL/6 strain has great regenerative potential, but DBA/2 strain shows inferior potential. In order to identify the 'factor' which regulates regenerative capacity, microarray analyses were performed. Sixty-nine genes were highly expressed in C57BL/6-derived myoblasts compared with DBA/2-derived myoblasts. Among 69 genes, 9 genes were also highly expressed in C57BL/6-derived mesenchymal progenitors that in DBA/2-derived them. Further analyses will lead to identify the regeneration promoting factor which might be a new therapeutic strategy for skeletal muscle disorders.
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[Journal Article] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression2013
Author(s)
Kanagawa M, Yu C, Ito C, Fukada S, Hozoji-Inada M, Chiyo T, Kuga A, Matuo M, Sato K, Yamaguchi M, Ito T, Katanosaka Y, Miyagoe-Suzuki Y, Naruse K, Kobayashi K, Okada T, Takeda S, Toda T
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Journal Title
Human Molecular Genetics
Volume: 22(15)
Pages: 3003-3015
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