2012 Fiscal Year Final Research Report
The ferritin independent antioxidant mechanism in intestinal mucosaof iron deficient rats.
| Project/Area Number |
23650485
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
SHINODA Shoko 首都大学東京, 人間健康科学研究科, 教授 (40132055)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食と栄養 |
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| Research Abstract |
In the small intestine of iron deficient rats, glutathione (GSH) concentrations were maintained highly as compared with iron sufficient rats. We found that the ferritin independent-antioxidant mechanism might inhibit adipose hyperoxidation in iron deficientrats. When iron was given to the ligated intestinal tract, labile iron pool in mucosal cells was rose in iron deficient group. GSH concentration was decreased by iron administration in both iron sufficient and deficient rats, but the rate of decline was bigger in iron deficient group. When total GSH concentration of intestinal mucosa was reduced by synthetic inhibitor of the GSH, adipose oxidation by iron was accelerated both in the iron deficient and sufficient groups.
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