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2011 Fiscal Year Final Research Report

Inflammatory responses and cancer initiated by Wnt signal network

Research Project

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Project/Area Number 23650594
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionOsaka University

Principal Investigator

KIKUCHI Akira  大阪大学, 医学系・研究科, 教授 (10204827)

Project Period (FY) 2011
KeywordsWnt / 炎症 / がん / 転移 / 抗体療法
Research Abstract

Chronic inflammation in microenvironment has been shown to be involved in cancer. This study examined regulation of inflammatory responses by Wnt signaling, which play important roles in cancer pathogenesis. Wnt5 enhanced LPS-dependent IL-6 expression in mouse peritoneal macrophages and the inflammatory responses were reduced in macrophages prepared from Wnt5a knockout mice. The addition of dextran sodium sulfate(DSS) generated a mouse model for bowel inflammatory diseases. Wnt5a knockout mice were resistant to DSS-induced inflammation. Taken together with the observations that expression of Wnt5a is involved in aggressiveness of cancer, these results suggest that Wnt5a signaling links between inflammation and cancer.

  • Research Products

    (24 results)

All 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] An Wnt5a-antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis2012

    • Author(s)
      Hanaki, H., Yamamoto, H., Sakane, H., Matsumoto, S., Ohdan, H., Sato, A., and Kikuchi, A
    • Journal Title

      Mol. Cancer Ther.

      Volume: 11 Pages: 298-307

    • Peer Reviewed
  • [Journal Article] Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling2012

    • Author(s)
      Sakane, H., Yamamoto, H., Matsumoto, S., Sato, A., and Kikuchi, A
    • Journal Title

      J. Cell Sci.

      Volume: 125 Pages: 449-460

    • Peer Reviewed
  • [Journal Article] Regulation of focal adhesion dynamics by Wnt5a signaling2012

    • Author(s)
      Matsumoto, S., and Kikuchi, A
    • Journal Title

      Methods in Mol. Biol.

      Volume: 839 Pages: 215-227

    • Peer Reviewed
  • [Journal Article] Wnt5a : its signaling, functions, and implication in diseases2012

    • Author(s)
      Kikuchi, A., Yamamoto, H., Sato, A., and Maysimoto, S
    • Journal Title

      Acta physiol

      Volume: 204 Pages: 17-33

    • Peer Reviewed
  • [Journal Article] Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates2011

    • Author(s)
      Miyamoto, T., Porazinski, S., Wang, H., Borovina, A., Ciruna, B., Shimizu, A., Kajii, T., Kikuchi, A., Furutani-Seiki, M., and Matsuura, S
    • Journal Title

      Hum. Mol. Genet.

      Volume: 20 Pages: 2058-2070

    • Peer Reviewed
  • [Journal Article] The transmembrane protein Waif1/ 5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization2011

    • Author(s)
      Kagermeier-Schenk, B., Wehner, D., Ozhan-Kizil, G., Yamamoto, H., Jian Li, Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G.
    • Journal Title

      Dev. Cell

      Volume: 21 Pages: 1129-1143

    • Peer Reviewed
  • [Journal Article] MMP-10/ Stromelysin-2 Promotes Invasion of Head and Neck Cancer2011

    • Author(s)
      Deraz, E. M., Kudo, Y., Yoshida, M., Obayashi, M., Tsunematsu, T., Tani, H., Siriwardena, S., Keikhaee, M. R., Qi, G., Iizuka, S., Ogawa, I., Campisi, G., Lo Muzio, L., Abiko, Y., Kikuchi, A., Takata, T
    • Journal Title

      PLoS ONE

      Volume: 6 Pages: e25438

    • Peer Reviewed
  • [Journal Article] New insights into the mechanism of Wnt signaling pathway activation2011

    • Author(s)
      Kikuchi, A., Yamamoto, H., Sato, A., Mastumoto, S
    • Journal Title

      Int. Rev. Cell. Mol. Biol

      Volume: 291 Pages: 21-71

    • Peer Reviewed
  • [Presentation] its signaling and implication in tumorigenesis2011

    • Author(s)
      Kikuchi, A.、Wnt5a
    • Organizer
      13th Japanese-German Cancer Workshop
    • Place of Presentation
      Hiroshima
    • Year and Date
      20111117-20
  • [Presentation] Growth factor-dependent regulation of cell polarity during tubulogenesis2011

    • Author(s)
      Kikuchi, A.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
  • [Presentation] BUBR1, a mitotic spindle checkpoint regulator, plays a role of ciliogenesis in G0 phrase2011

    • Author(s)
      Miyamoto, T., Porazinski, S., Huijia, W., Shimizu, A., Kajii, T. Kikuchi, A., Furutani-Seiki, M., Shinya Matsuura, S.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
  • [Presentation] Novel fuction of Dvl, a Wnt signaling molecule, in cytokinesis2011

    • Author(s)
      Fumoto, k., Kikuchi, K., Kikuchi, A.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
  • [Presentation] Dissecting the novel functions of Axin and Prickle in cell polarization and directional migration2011

    • Author(s)
      Lim, Boon Cheng., Matsumoto, S., Kikuchi, A.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
  • [Presentation] Wnt3a and Wnt5a regulate epithelial polarity and tubulogenesis cooperatively2011

    • Author(s)
      Matsumoto, S., Kikuchi, A.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
  • [Presentation] Wnt5a deficiency ameliorates the dextran sulfate sodium(DSS)-induced acute colitis2011

    • Author(s)
      Sato, A., Shojima, K., Koyama, H., Kikuchi, A.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
  • [Presentation] GSK3β/ Axin-1/β-catenin Complex is involved In Semaphorin3A Signaling2011

    • Author(s)
      Hida, T., Yamashita, N., Usui, H., Nakamura, F., Kikuchi, A., Goshima, Y.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
  • [Presentation] Development of new therapeutic methods for cancer expressing Wnt5a by the use of anti-Wnt5a antibody2011

    • Author(s)
      Hanaki, H., Yamamoto, H., Kikuchi, A.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
  • [Presentation] The role of h-prune in anaplastic thyroid cancer cell migration and invasion2011

    • Author(s)
      Nambu, J., Kobayashi, T., Tashiro, H., Sugino, K., Shimamoto, F., Kikuchi, A. Ohdan, H.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] BUBR1, a mitotic spindle checkpoint regulator, regulates ciliogenesis in G0 phase2011

    • Author(s)
      Miyamoto, T., Kikuchi, A., Furutani-Seiki, M., Matsuura, S.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] The Dvl-associating protein Daple controls Rac activation and cell migration2011

    • Author(s)
      Ishida, M., Enomoto, A., Kikuchi, A., Takahashi, M.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] Glypican-4の脂質ラフトへの局在に依存したWntシグナル伝達の制御機構2011

    • Author(s)
      坂根洋、山本英樹、松本真司、佐藤朗、菊池章
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
  • [Presentation] 翻訳後修飾によるWnt蛋白質の機能発現の制御2011

    • Author(s)
      山本英樹、粟田ちひろ、高尾敏文、岸田昭世、岸田想子、菊池章
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
  • [Presentation] Wntシグナルによる上皮形態形成制御とその異常による病態2011

    • Author(s)
      菊池章
    • Organizer
      第84回内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-22
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/molbiobc/index.html

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Published: 2013-07-31  

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