2013 Fiscal Year Final Research Report
Characterization of genetic factors that modify the risk of cancer and could be useful for the development of new cancer prevantion drugs
| Project/Area Number |
23650624
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
DAIGO YATARO 滋賀医科大学, 医学部, 教授 (30345029)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 分子標的治療 |
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| Research Abstract |
Cancer is the most common cause of death in Japan, and its incidence is increasing worldwide. To identify genetic factors that modify the risk of human cancer and could be therapeutic targets for the development of new anti-cancer drugs, we conducted a genome-wide association study in a Japanese lung cancer population and identified some susceptibility genes for lung cancer. We established cell lines stably expressing these risk factor genes and examined their mechanism in cancer progression to make a new drug screening system. The results could contribute to new drug design targeting genetic variation that may influence susceptibility to human cancer.
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[Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer2013
Author(s)
Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y
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Journal Title
Mol Cancer Res
Volume: 11
Pages: 937-951
DOI
Peer Reviewed
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[Journal Article] Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition2013
Author(s)
Kogurea M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, Kobayashi T, Daigo Y, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R
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Journal Title
Cancer Lett
Volume: 336
Pages: 76-84
DOI
Peer Reviewed
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[Journal Article] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population2012
Author(s)
Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
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Journal Title
Nature Genetics
Volume: 44
Pages: 900-903
DOI
Peer Reviewed
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[Journal Article] Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B2012
Author(s)
Cho HS, Shimazu T, Toyokawa G, Daigo Y, Maehara Y, Hayami S, Ito A, Masuda K, Ikawa N, Field HI, Tsuchiya E, Ohnuma S, Ponder BA, Yoshida M, Nakamura Y, Hamamoto R
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Journal Title
Nature Communications
Volume: 3
Pages: 1072
DOI
Peer Reviewed
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